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320 results

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Page 1
Tracking clonal evolution of drug resistance in ovarian cancer patients by exploiting structural variants in cfDNA.
Williams MJ, Vázquez-García I, Tam G, Wu M, Varice N, Havasov E, Shi H, Satas G, Lees HJ, Lee JJ, Myers MA, Zatzman M, Rusk N, Ali E, Shah RH, Berger MF, Mohibullah N, Lakhman Y, Chi DS, Abu-Rustum NR, Aghajanian C, McPherson A, Zamarin D, Loomis B, Weigelt B, Friedman CF, Shah SP. Williams MJ, et al. Among authors: aghajanian c. bioRxiv [Preprint]. 2024 Aug 23:2024.08.21.609031. doi: 10.1101/2024.08.21.609031. bioRxiv. 2024. PMID: 39229105 Free PMC article. Preprint.
Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer.
McPherson A, Vázquez-García I, Myers MA, Zatzman M, Al-Rawi D, Weiner A, Freeman S, Mohibullah N, Satas G, Williams MJ, Ceglia N, Zhang AW, Li J, Lim JLP, Wu M, Choi S, Havasov E, Grewal D, Shi H, Kim M, Schwarz R, Kaufmann T, Dinh KN, Uhlitz F, Tran J, Wu Y, Patel R, Ramakrishnan S, Kim D, Clarke J, Green H, Ali E, DiBona M, Varice N, Kundra R, Broach V, Gardner GJ, Roche KL, Sonoda Y, Zivanovic O, Kim SH, Grisham RN, Liu YL, Viale A, Rusk N, Lakhman Y, Ellenson LH, Tavaré S, Aparicio S, Chi DS, Aghajanian C, Abu-Rustum NR, Friedman CF, Zamarin D, Weigelt B, Bakhoum SF, Shah SP. McPherson A, et al. Among authors: aghajanian c. bioRxiv [Preprint]. 2024 Jul 15:2024.07.11.602772. doi: 10.1101/2024.07.11.602772. bioRxiv. 2024. PMID: 39071261 Free PMC article. Preprint.
Olaparib as treatment for platinum-sensitive relapsed ovarian cancer by BRCA mutation and homologous recombination deficiency: Phase 2 LIGHT study final overall survival analysis.
Liu YL, Mathews CA, Simpkins F, Cadoo KA, Provencher D, McCormick CC, ElNaggar AC, Altman AD, Gilbert L, Black D, Kabil N, Taylor RN, Barnicle A, Munley JY, Aghajanian C. Liu YL, et al. Among authors: aghajanian c. Cancer. 2025 Jan 15;131(2):e35707. doi: 10.1002/cncr.35707. Cancer. 2025. PMID: 39817648 Free PMC article. Clinical Trial.
Neoadjuvant or concurrent atezolizumab with chemoradiation for locally advanced cervical cancer: a randomized phase I trial.
Mayadev J, Zamarin D, Deng W, Lankes HA, Pesci G, Kim H, Chino JP, Banbury B, Sherry N, Sharon E, Ghamande SA, Ferguson C, Mell L, Holman L, Mathews C, O'Malley D, Olawaiye A, Hopp E, Leath C 3rd, Copeland L, Mannel R, O'Cearbhaill R, Aghajanian C, Schilder RJ. Mayadev J, et al. Among authors: aghajanian c. Nat Commun. 2025 Jan 9;16(1):553. doi: 10.1038/s41467-024-55200-2. Nat Commun. 2025. PMID: 39788967 Free PMC article. Clinical Trial.
Optimizing Mainstreaming of Genetic Testing in Parallel With Ovarian and Endometrial Cancer Tumor Testing: How Do We Maximize Our Impact?
Liu YL, Sia TY, Varice N, Wu M, Byrne M, Khurram A, Kemel Y, Sheehan M, Galle J, Sabbatini P, Brown C, Roche KL, Chi D, Solit DB, Mueller J, Stadler ZK, Hamilton JG, Aghajanian C, Abu-Rustum NR. Liu YL, et al. Among authors: aghajanian c. JCO Precis Oncol. 2024 Dec;8:e2400525. doi: 10.1200/PO-24-00525. Epub 2024 Dec 23. JCO Precis Oncol. 2024. PMID: 39715484
Patterns of genomic instability in > 2000 patients with ovarian cancer across six clinical trials evaluating olaparib.
Barnicle A, Ray-Coquard I, Rouleau E, Cadoo K, Simpkins F, Aghajanian C, Leary A, Poveda A, Lheureux S, Pujade-Lauraine E, You B, Ledermann J, Matulonis U, Gourley C, Timms KM, Lai Z, Hodgson DR, Elks CE, Dearden S, Egile C, Lao-Sirieix P, Harrington EA, Brown JS. Barnicle A, et al. Among authors: aghajanian c. Genome Med. 2024 Dec 18;16(1):145. doi: 10.1186/s13073-024-01413-5. Genome Med. 2024. PMID: 39695768 Free PMC article.
Association between genomic instability score and progression-free/overall survival in patients with newly diagnosed non-BRCA1/2 ovarian cancer.
Graves S, Sullivan MW, Adkoli A, Zhou Q, Iasonos A, Selenica P, Aghajanian C, Liu YL, Tew W, Sonoda Y, Ellenson LH, Chi D, O'Cearbhaill RE, Weigelt B, Grisham RN. Graves S, et al. Among authors: aghajanian c. Gynecol Oncol. 2024 Dec 7;192:120-127. doi: 10.1016/j.ygyno.2024.11.011. Online ahead of print. Gynecol Oncol. 2024. PMID: 39647188
A Phase II Study of Fulvestrant plus Abemaciclib in Hormone Receptor-Positive Advanced or Recurrent Endometrial Cancer.
Green AK, Zhou Q, Iasonos A, Zammarrelli WA, Weigelt B, Ellenson LH, Chhetri-Long R, Shah P, Loh J, Hom V, Selenica P, Erinjeri J, Petkovska I, Chandarlapaty S, Cohen S, Grisham R, Konner J, Rubinstein MM, Tew W, Troso-Sandoval T, Aghajanian C, Makker V. Green AK, et al. Among authors: aghajanian c. Clin Cancer Res. 2024 Nov 19. doi: 10.1158/1078-0432.CCR-24-1999. Online ahead of print. Clin Cancer Res. 2024. PMID: 39561275
320 results