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195 results

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Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes.
Tang YJ, Xu H, Hughes NW, Kim SH, Ruiz P, Shuldiner EG, Lopez SS, Hebert JD, Karmakar S, Andrejka L, Dolcen DN, Boross G, Chu P, Detrick C, Pierce S, Ashkin EL, Greenleaf WJ, Voss AK, Thomas T, van de Rijn M, Petrov DA, Winslow MM. Tang YJ, et al. Among authors: petrov da. bioRxiv [Preprint]. 2024 Aug 20:2024.08.19.607671. doi: 10.1101/2024.08.19.607671. bioRxiv. 2024. PMID: 39229041 Free PMC article. Preprint.
Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth.
Tang R, Shuldiner EG, Kelly M, Murray CW, Hebert JD, Andrejka L, Tsai MK, Hughes NW, Parker MI, Cai H, Li YC, Wahl GM, Dunbrack RL, Jackson PK, Petrov DA, Winslow MM. Tang R, et al. Among authors: petrov da. Nat Cell Biol. 2023 Jan;25(1):159-169. doi: 10.1038/s41556-022-01049-w. Epub 2023 Jan 12. Nat Cell Biol. 2023. PMID: 36635501 Free PMC article.
A multiplexed in vivo approach to identify driver genes in small cell lung cancer.
Lee MC, Cai H, Murray CW, Li C, Shue YT, Andrejka L, He AL, Holzem AME, Drainas AP, Ko JH, Coles GL, Kong C, Zhu S, Zhu C, Wang J, van de Rijn M, Petrov DA, Winslow MM, Sage J. Lee MC, et al. Among authors: petrov da. Cell Rep. 2023 Jan 31;42(1):111990. doi: 10.1016/j.celrep.2023.111990. Epub 2023 Jan 13. Cell Rep. 2023. PMID: 36640300 Free PMC article.
Fully accessible fitness landscape of oncogene-negative lung adenocarcinoma.
Yousefi M, Andrejka L, Szamecz M, Winslow MM, Petrov DA, Boross G. Yousefi M, et al. Among authors: petrov da. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2303224120. doi: 10.1073/pnas.2303224120. Epub 2023 Sep 11. Proc Natl Acad Sci U S A. 2023. PMID: 37695905 Free PMC article.
A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis.
Ashkin EL, Tang YJ, Xu H, Hung KL, Belk J, Cai H, Lopez S, Dolcen DN, Hebert JD, Li R, Ruiz PA, Keal T, Andrejka L, Chang HY, Petrov DA, Dixon JR, Xu Z, Winslow MM. Ashkin EL, et al. Among authors: petrov da. bioRxiv [Preprint]. 2024 Sep 19:2024.09.14.613043. doi: 10.1101/2024.09.14.613043. bioRxiv. 2024. PMID: 39345539 Free PMC article. Preprint.
Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network.
Boutelle AM, Mabene AR, Yao D, Xu H, Wang M, Tang YJ, Lopez SS, Sinha S, Demeter J, Cheng R, Benard BA, Valente LJ, Drainas AP, Fischer M, Majeti R, Petrov DA, Jackson PK, Yang F, Winslow MM, Bassik MC, Attardi LD. Boutelle AM, et al. Among authors: petrov da. bioRxiv [Preprint]. 2024 Sep 18:2024.09.17.612743. doi: 10.1101/2024.09.17.612743. bioRxiv. 2024. PMID: 39345444 Free PMC article. Preprint.
Oncogenic context shapes the fitness landscape of tumor suppression.
Blair LM, Juan JM, Sebastian L, Tran VB, Nie W, Wall GD, Gerceker M, Lai IK, Apilado EA, Grenot G, Amar D, Foggetti G, Do Carmo M, Ugur Z, Deng D, Chenchik A, Paz Zafra M, Dow LE, Politi K, MacQuitty JJ, Petrov DA, Winslow MM, Rosen MJ, Winters IP. Blair LM, et al. Among authors: petrov da. Nat Commun. 2023 Oct 12;14(1):6422. doi: 10.1038/s41467-023-42156-y. Nat Commun. 2023. PMID: 37828026 Free PMC article.
195 results