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Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models.
Pietrogrande G, Shaker MR, Stednitz SJ, Soheilmoghaddam F, Aguado J, Morrison SD, Zambrano S, Tabassum T, Javed I, Cooper-White J, Davis TP, O'Brien TJ, Scott EK, Wolvetang EJ. Pietrogrande G, et al. Among authors: aguado j. Mol Psychiatry. 2024 Sep 3. doi: 10.1038/s41380-024-02732-0. Online ahead of print. Mol Psychiatry. 2024. PMID: 39227432
Klotho inhibits neuronal senescence in human brain organoids.
Shaker MR, Aguado J, Chaggar HK, Wolvetang EJ. Shaker MR, et al. Among authors: aguado j. NPJ Aging Mech Dis. 2021 Aug 2;7(1):18. doi: 10.1038/s41514-021-00070-x. NPJ Aging Mech Dis. 2021. PMID: 34341344 Free PMC article.
Exploring aging interventions in human brain organoids.
Aguado J, Wolvetang EJ. Aguado J, et al. Aging (Albany NY). 2022 Feb 28;14(4):1592-1593. doi: 10.18632/aging.203925. Epub 2022 Feb 28. Aging (Albany NY). 2022. PMID: 35247254 Free PMC article. No abstract available.
Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution.
Taherian Fard A, Leeson HC, Aguado J, Pietrogrande G, Power D, Gómez-Inclán C, Zheng H, Nelson CB, Soheilmoghaddam F, Glass N, Dharmaratne M, Watson ER, Lu J, Martin S, Pickett HA, Cooper-White J, Wolvetang EJ, Mar JC. Taherian Fard A, et al. Among authors: aguado j. Geroscience. 2024 Feb;46(1):999-1015. doi: 10.1007/s11357-023-00829-y. Epub 2023 Jun 14. Geroscience. 2024. PMID: 37314668 Free PMC article.
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.
Albornoz EA, Amarilla AA, Modhiran N, Parker S, Li XX, Wijesundara DK, Aguado J, Zamora AP, McMillan CLD, Liang B, Peng NYG, Sng JDJ, Saima FT, Fung JN, Lee JD, Paramitha D, Parry R, Avumegah MS, Isaacs A, Lo MW, Miranda-Chacon Z, Bradshaw D, Salinas-Rebolledo C, Rajapakse NW, Wolvetang EJ, Munro TP, Rojas-Fernandez A, Young PR, Stacey KJ, Khromykh AA, Chappell KJ, Watterson D, Woodruff TM. Albornoz EA, et al. Among authors: aguado j. Mol Psychiatry. 2023 Jul;28(7):2878-2893. doi: 10.1038/s41380-022-01831-0. Epub 2022 Nov 1. Mol Psychiatry. 2023. PMID: 36316366 Free PMC article.
Cellular senescence and premature aging in Down Syndrome.
Peng L, Baradar AA, Aguado J, Wolvetang E. Peng L, et al. Among authors: aguado j. Mech Ageing Dev. 2023 Jun;212:111824. doi: 10.1016/j.mad.2023.111824. Epub 2023 May 24. Mech Ageing Dev. 2023. PMID: 37236373 Review.
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.
Aguado J, Amarilla AA, Taherian Fard A, Albornoz EA, Tyshkovskiy A, Schwabenland M, Chaggar HK, Modhiran N, Gómez-Inclán C, Javed I, Baradar AA, Liang B, Peng L, Dharmaratne M, Pietrogrande G, Padmanabhan P, Freney ME, Parry R, Sng JDJ, Isaacs A, Khromykh AA, Valenzuela Nieto G, Rojas-Fernandez A, Davis TP, Prinz M, Bengsch B, Gladyshev VN, Woodruff TM, Mar JC, Watterson D, Wolvetang EJ. Aguado J, et al. Nat Aging. 2023 Dec;3(12):1561-1575. doi: 10.1038/s43587-023-00519-6. Epub 2023 Nov 13. Nat Aging. 2023. PMID: 37957361 Free PMC article.
Telomere transcription in ageing.
Aguado J, d'Adda di Fagagna F, Wolvetang E. Aguado J, et al. Ageing Res Rev. 2020 Sep;62:101115. doi: 10.1016/j.arr.2020.101115. Epub 2020 Jun 18. Ageing Res Rev. 2020. PMID: 32565330 Review.
The hallmarks of aging in Ataxia-Telangiectasia.
Aguado J, Gómez-Inclán C, Leeson HC, Lavin MF, Shiloh Y, Wolvetang EJ. Aguado J, et al. Ageing Res Rev. 2022 Aug;79:101653. doi: 10.1016/j.arr.2022.101653. Epub 2022 May 26. Ageing Res Rev. 2022. PMID: 35644374 Free article. Review.
680 results