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Page 1
A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors.
Brands J, Bravo S, Jürgenliemke L, Grätz L, Schihada H, Frechen F, Alenfelder J, Pfeil C, Ohse PG, Hiratsuka S, Kawakami K, Schmacke LC, Heycke N, Inoue A, König G, Pfeifer A, Wachten D, Schulte G, Steinmetzer T, Watts VJ, Gomeza J, Simon K, Kostenis E. Brands J, et al. Among authors: heycke n. Nat Commun. 2024 Sep 3;15(1):7684. doi: 10.1038/s41467-024-51991-6. Nat Commun. 2024. PMID: 39227390 Free PMC article.
Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs.
Pfeil EM, Brands J, Merten N, Vögtle T, Vescovo M, Rick U, Albrecht IM, Heycke N, Kawakami K, Ono Y, Ngako Kadji FM, Hiratsuka S, Aoki J, Häberlein F, Matthey M, Garg J, Hennen S, Jobin ML, Seier K, Calebiro D, Pfeifer A, Heinemann A, Wenzel D, König GM, Nieswandt B, Fleischmann BK, Inoue A, Simon K, Kostenis E. Pfeil EM, et al. Among authors: heycke n. Mol Cell. 2020 Dec 17;80(6):940-954.e6. doi: 10.1016/j.molcel.2020.10.027. Epub 2020 Nov 16. Mol Cell. 2020. PMID: 33202251 Free article.
An experimental strategy to probe Gq contribution to signal transduction in living cells.
Patt J, Alenfelder J, Pfeil EM, Voss JH, Merten N, Eryilmaz F, Heycke N, Rick U, Inoue A, Kehraus S, Deupi X, Müller CE, König GM, Crüsemann M, Kostenis E. Patt J, et al. Among authors: heycke n. J Biol Chem. 2021 Jan-Jun;296:100472. doi: 10.1016/j.jbc.2021.100472. Epub 2021 Feb 25. J Biol Chem. 2021. PMID: 33639168 Free PMC article.
Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.
Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E. Annala S, et al. Among authors: heycke n. Sci Signal. 2019 Mar 19;12(573):eaau5948. doi: 10.1126/scisignal.aau5948. Sci Signal. 2019. PMID: 30890659
An environmental bacterial taxon with a large and distinct metabolic repertoire.
Wilson MC, Mori T, Rückert C, Uria AR, Helf MJ, Takada K, Gernert C, Steffens UA, Heycke N, Schmitt S, Rinke C, Helfrich EJ, Brachmann AO, Gurgui C, Wakimoto T, Kracht M, Crüsemann M, Hentschel U, Abe I, Matsunaga S, Kalinowski J, Takeyama H, Piel J. Wilson MC, et al. Among authors: heycke n. Nature. 2014 Feb 6;506(7486):58-62. doi: 10.1038/nature12959. Epub 2014 Jan 29. Nature. 2014. PMID: 24476823 Free article.