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Targeting the membrane-proximal C2-set domain of CD33 for improved CAR T cell therapy.
Fiorenza S, Lim SYT, Laszlo GS, Kimble EL, Phi TD, Lunn-Halbert MC, Kirchmeier DR, Huo J, Kiem HP, Turtle CJ, Walter RB. Fiorenza S, et al. Among authors: phi td. Mol Ther Oncol. 2024 Jul 31;32(3):200854. doi: 10.1016/j.omton.2024.200854. eCollection 2024 Sep 19. Mol Ther Oncol. 2024. PMID: 39224504 Free PMC article.
Factors associated with outcomes after a second CD19-targeted CAR T-cell infusion for refractory B-cell malignancies.
Gauthier J, Bezerra ED, Hirayama AV, Fiorenza S, Sheih A, Chou CK, Kimble EL, Pender BS, Hawkins RM, Vakil A, Phi TD, Steinmetz RN, Jamieson AW, Bar M, Cassaday RD, Chapuis AG, Cowan AJ, Green DJ, Kiem HP, Milano F, Shadman M, Till BG, Riddell SR, Maloney DG, Turtle CJ. Gauthier J, et al. Among authors: phi td. Blood. 2021 Jan 21;137(3):323-335. doi: 10.1182/blood.2020006770. Blood. 2021. PMID: 32967009 Free PMC article. Clinical Trial.
Histone marks identify novel transcription factors that parse CAR-T subset-of-origin, clinical potential and expansion.
Fiorenza S, Zheng Y, Purushe J, Bock TJ, Sarthy J, Janssens DH, Sheih AS, Kimble EL, Kirchmeier D, Phi TD, Gauthier J, Hirayama AV, Riddell SR, Wu Q, Gottardo R, Maloney DG, Yang JYH, Henikoff S, Turtle CJ. Fiorenza S, et al. Among authors: phi td. Nat Commun. 2024 Sep 27;15(1):8309. doi: 10.1038/s41467-024-52503-2. Nat Commun. 2024. PMID: 39333103 Free PMC article.
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager.
Crook ZR, Girard EJ, Sevilla GP, Brusniak MY, Rupert PB, Friend DJ, Gewe MM, Clarke M, Lin I, Ruff R, Pakiam F, Phi TD, Bandaranayake A, Correnti CE, Mhyre AJ, Nairn NW, Strong RK, Olson JM. Crook ZR, et al. Among authors: phi td. Sci Transl Med. 2022 May 18;14(645):eabn0402. doi: 10.1126/scitranslmed.abn0402. Epub 2022 May 18. Sci Transl Med. 2022. PMID: 35584229 Free PMC article.
20 results