Fernández-Ruiz J - Search Results

1

Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.

Aebi J, Atz K, Ametamey SM, Benz J, Blaising J, Butini S, Campiani G, Carreira EM, Collin L, De Lago E, Gazzi T, Gertsch J, Gobbi L, Guba W, Fernández-Ruiz J, Fingerle J, Haider A, He Y, Heitman LH, Honer M, Hunziker D, Kuhn B, Maccarrone M, Märki HP, Martin RE, Mohr P, Mu L, Nazaré M, Nippa DF, Oddi S, O'Hara F, Pacher P, Romero J, Röver S, Rufer AC, Schibli R, Schneider G, Stepan AF, Sykes DA, Ullmer C, Van der Stelt M, Veprintsev DB, Wittwer MB, Grether U. Aebi J, et al. Among authors: fernandez ruiz j. Chimia (Aarau). 2024 Aug 21;78(7-8):499-512. doi: 10.2533/chimia.2024.499. Chimia (Aarau). 2024. PMID: 39221845 Free article.

2

UCM707, a potent and selective inhibitor of endocannabinoid uptake, potentiates hypokinetic and antinociceptive effects of anandamide.

de Lago E, Fernández-Ruiz J, Ortega-Gutiérrez S, Viso A, López-Rodríguez ML, Ramos JA. de Lago E, et al. Eur J Pharmacol. 2002 Aug 2;449(1-2):99-103. doi: 10.1016/s0014-2999(02)01996-9. Eur J Pharmacol. 2002. PMID: 12163112

3

The endogenous cannabinoid system and the basal ganglia. biochemical, pharmacological, and therapeutic aspects.

Romero J, Lastres-Becker I, de Miguel R, Berrendero F, Ramos JA, Fernández-Ruiz J. Romero J, et al. Pharmacol Ther. 2002 Aug;95(2):137-52. doi: 10.1016/s0163-7258(02)00253-x. Pharmacol Ther. 2002. PMID: 12182961 Review.

4

Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.

López-Rodríguez ML, Viso A, Ortega-Gutiérrez S, Fowler CJ, Tiger G, de Lago E, Fernández-Ruiz J, Ramos JA. López-Rodríguez ML, et al. J Med Chem. 2003 Apr 10;46(8):1512-22. doi: 10.1021/jm0210818. J Med Chem. 2003. PMID: 12672252

5

Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors.

López-Rodríguez ML, Viso A, Ortega-Gutiérrez S, Fowler CJ, Tiger G, de Lago E, Fernández-Ruiz J, Ramos JA. López-Rodríguez ML, et al. Eur J Med Chem. 2003 Apr;38(4):403-12. doi: 10.1016/s0223-5234(03)00045-x. Eur J Med Chem. 2003. PMID: 12750028

6

In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake.

de Lago E, Ligresti A, Ortar G, Morera E, Cabranes A, Pryce G, Bifulco M, Baker D, Fernandez-Ruiz J, Di Marzo V. de Lago E, et al. Eur J Pharmacol. 2004 Jan 26;484(2-3):249-57. doi: 10.1016/j.ejphar.2003.11.027. Eur J Pharmacol. 2004. PMID: 14744610

7

Involvement of vanilloid-like receptors in the effects of anandamide on motor behavior and nigrostriatal dopaminergic activity: in vivo and in vitro evidence.

de Lago E, de Miguel R, Lastres-Becker I, Ramos JA, Fernández-Ruiz J. de Lago E, et al. Brain Res. 2004 May 8;1007(1-2):152-9. doi: 10.1016/j.brainres.2004.02.016. Brain Res. 2004. PMID: 15064146

8

Effect of repeated systemic administration of selective inhibitors of endocannabinoid inactivation on rat brain endocannabinoid levels.

de Lago E, Petrosino S, Valenti M, Morera E, Ortega-Gutierrez S, Fernandez-Ruiz J, Di Marzo V. de Lago E, et al. Biochem Pharmacol. 2005 Aug 1;70(3):446-52. doi: 10.1016/j.bcp.2005.05.011. Biochem Pharmacol. 2005. PMID: 15963472

9

Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease.

de Lago E, Urbani P, Ramos JA, Di Marzo V, Fernández-Ruiz J. de Lago E, et al. Brain Res. 2005 Jul 19;1050(1-2):210-6. doi: 10.1016/j.brainres.2005.05.024. Brain Res. 2005. PMID: 15975564

10

UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.

de Lago E, Fernández-Ruiz J, Ortega-Gutiérrez S, Cabranes A, Pryce G, Baker D, López-Rodríguez M, Ramos JA. de Lago E, et al. Eur Neuropsychopharmacol. 2006 Jan;16(1):7-18. doi: 10.1016/j.euroneuro.2005.06.001. Epub 2005 Jul 11. Eur Neuropsychopharmacol. 2006. PMID: 16006105

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