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Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models.
Havel V, Kruegel AC, Bechand B, McIntosh S, Stallings L, Hodges A, Wulf MG, Nelson M, Hunkele A, Ansonoff M, Pintar JE, Hwu C, Ople RS, Abi-Gerges N, Zaidi SA, Katritch V, Yang M, Javitch JA, Majumdar S, Hemby SE, Sames D. Havel V, et al. Among authors: ople rs. Nat Commun. 2024 Sep 20;15(1):8118. doi: 10.1038/s41467-024-51856-y. Nat Commun. 2024. PMID: 39304653 Free PMC article.
Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR.
Ople RS, Ramos-Gonzalez N, Li Q, Sobecks BL, Aydin D, Powers AS, Faouzi A, Polacco BJ, Bernhard SM, Appourchaux K, Sribhashyam S, Eans SO, Tsai BA, Dror RO, Varga BR, Wang H, Hüttenhain R, McLaughlin JP, Majumdar S. Ople RS, et al. ACS Cent Sci. 2024 Jul 17;10(8):1490-1503. doi: 10.1021/acscentsci.4c00525. eCollection 2024 Aug 28. ACS Cent Sci. 2024. PMID: 39220695 Free PMC article.
Synthesis of novel N-cyclopentenyl-lactams using the Aubé reaction.
Shinde MV, Ople RS, Sangtani E, Gonnade R, Reddy DS. Shinde MV, et al. Among authors: ople rs. Beilstein J Org Chem. 2015 Jun 23;11:1060-7. doi: 10.3762/bjoc.11.119. eCollection 2015. Beilstein J Org Chem. 2015. PMID: 26199661 Free PMC article.