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Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.
Akindehin S, Liskiewicz A, Liskiewicz D, Bernecker M, Garcia-Caceres C, Drucker DJ, Finan B, Grandl G, Gutgesell R, Hofmann SM, Khalil A, Liu X, Cota P, Bakhti M, Czarnecki O, Bastidas-Ponce A, Lickert H, Kang L, Maity G, Novikoff A, Parlee S, Pathak E, Schriever SC, Sterr M, Ussar S, Zhang Q, DiMarchi R, Tschöp MH, Pfluger PT, Douros JD, Müller TD. Akindehin S, et al. Among authors: drucker dj. Mol Metab. 2024 May;83:101915. doi: 10.1016/j.molmet.2024.101915. Epub 2024 Mar 14. Mol Metab. 2024. PMID: 38492844 Free PMC article.
Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis.
Suba K, Patel Y, Martin-Alonso A, Hansen B, Xu X, Roberts A, Norton M, Chung P, Shrewsbury J, Kwok R, Kalogianni V, Chen S, Liu X, Kalyviotis K, Rutter GA, Jones B, Minnion J, Owen BM, Pantazis P, Distaso W, Drucker DJ, Tan TM, Bloom SR, Murphy KG, Salem V. Suba K, et al. Among authors: drucker dj. Mol Metab. 2024 Jul;85:101947. doi: 10.1016/j.molmet.2024.101947. Epub 2024 Apr 26. Mol Metab. 2024. PMID: 38677509 Free PMC article.
Characterization of LY3324954 a long-acting glucagon-receptor agonist.
Roell W, Coskun T, Kim T, O'Farrell L, Martin JA, Nason S, Hernandez-Alamillo J, Dhantu S, Drucker DJ, Sloop KW, Steele JP, Alsina-Fernandez J, Habegger KM. Roell W, et al. Among authors: drucker dj. Mol Metab. 2025 Jan;91:102073. doi: 10.1016/j.molmet.2024.102073. Epub 2024 Nov 25. Mol Metab. 2025. PMID: 39603505 Free PMC article.
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease.
Wang MY, Zhang Z, Zhao S, Onodera T, Sun XN, Zhu Q, Li C, Li N, Chen S, Paredes M, Gautron L, Charron MJ, Marciano DK, Gordillo R, Drucker DJ, Scherer PE. Wang MY, et al. Among authors: drucker dj. Cell Metab. 2024 Mar 5;36(3):575-597.e7. doi: 10.1016/j.cmet.2023.12.024. Epub 2024 Jan 17. Cell Metab. 2024. PMID: 38237602
425 results