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Evaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs.
Actis M, Cresser-Brown J, Caine EA, Steger M, Aggarwal A, Mayasundari A, Murphy N, Valinciute G, Li Y, Fu X, Yang L, Marsh G, Hughes G, Karadogan B, Wheeler D, Norley M, Spain F, Urh M, Roussel MF, Schwalb B, Daub H, Riching KM, Maple H, Nishiguchi G, Rankovic Z. Actis M, et al. Among authors: li y. J Med Chem. 2025 Jan 15. doi: 10.1021/acs.jmedchem.4c02709. Online ahead of print. J Med Chem. 2025. PMID: 39813384
The Golgi complex governs natural killer cell lytic granule positioning to promote directionality in cytotoxicity.
Pedroza LA, van den Haak F, Frumovitz A, Hernandez E, Hegewisch-Solloa E, Orange TK, Sheehan KB, Prockop S, Bodansky A, Chinn IK, Lupski JR, Posey JE, Mace EM, Li Y, Orange JS. Pedroza LA, et al. Among authors: li y. Cell Rep. 2025 Jan 13;44(1):115156. doi: 10.1016/j.celrep.2024.115156. Online ahead of print. Cell Rep. 2025. PMID: 39813120
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