Zhou H - Search Results

1

IL-10R inhibition reprograms tumor-associated macrophages and reverses drug resistance in multiple myeloma.

Sun J, Corradini S, Azab F, Shokeen M, Muz B, Miari KE, Maksimos M, Diedrich C, Asare O, Alhallak K, Park C, Lubben B, Chen Y, Adebayo O, Bash H, Kelley S, Fiala M, Bender DE, Zhou H, Wang S, Vij R, Williams MTS, Azab AK. Sun J, et al. Among authors: zhou h. Leukemia. 2024 Nov;38(11):2355-2365. doi: 10.1038/s41375-024-02391-8. Epub 2024 Aug 30. Leukemia. 2024. PMID: 39215060 Free PMC article.

2

BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo.

Bai L, Chen J, McEachern D, Liu L, Zhou H, Aguilar A, Wang S. Bai L, et al. Among authors: zhou h. PLoS One. 2014 Jun 5;9(6):e99404. doi: 10.1371/journal.pone.0099404. eCollection 2014. PLoS One. 2014. PMID: 24901320 Free PMC article.

3

Targeting DCN1-UBC12 Protein-Protein Interaction for Regulation of Neddylation Pathway.

Zhou H, Lu J, Yang CY, Sun Y, Wang S. Zhou H, et al. Adv Exp Med Biol. 2020;1217:349-362. doi: 10.1007/978-981-15-1025-0_20. Adv Exp Med Biol. 2020. PMID: 31898237 Review.

4

SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.

Zhou H, Bai L, Xu R, McEachern D, Chinnaswamy K, Li R, Wen B, Wang M, Yang CY, Meagher JL, Sun D, Stuckey JA, Wang S. Zhou H, et al. ACS Med Chem Lett. 2021 May 10;12(6):996-1004. doi: 10.1021/acsmedchemlett.1c00155. eCollection 2021 Jun 10. ACS Med Chem Lett. 2021. PMID: 34141084 Free PMC article.

5

Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.

Xu R, Zhou H, Bai L, McEachern D, Wu D, Acharyya RK, Wang M, Tošović J, Yang CY, Chinnaswamy K, Meagher JL, Stuckey JA, Liu C, Wang M, Wen B, Sun D, Wang S. Xu R, et al. Among authors: zhou h. J Med Chem. 2024 Nov 28;67(22):20495-20513. doi: 10.1021/acs.jmedchem.4c01946. Epub 2024 Nov 7. J Med Chem. 2024. PMID: 39509603

6

Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold.

Zhou H, Chen J, Meagher JL, Yang CY, Aguilar A, Liu L, Bai L, Cong X, Cai Q, Fang X, Stuckey JA, Wang S. Zhou H, et al. J Med Chem. 2012 May 24;55(10):4664-82. doi: 10.1021/jm300178u. Epub 2012 May 10. J Med Chem. 2012. PMID: 22448988 Free PMC article.

7

Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.

Zhou H, Aguilar A, Chen J, Bai L, Liu L, Meagher JL, Yang CY, McEachern D, Cong X, Stuckey JA, Wang S. Zhou H, et al. J Med Chem. 2012 Jul 12;55(13):6149-61. doi: 10.1021/jm300608w. Epub 2012 Jul 2. J Med Chem. 2012. PMID: 22747598 Free PMC article.

8

Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.

Chen J, Zhou H, Aguilar A, Liu L, Bai L, McEachern D, Yang CY, Meagher JL, Stuckey JA, Wang S. Chen J, et al. Among authors: zhou h. J Med Chem. 2012 Oct 11;55(19):8502-14. doi: 10.1021/jm3010306. Epub 2012 Oct 2. J Med Chem. 2012. PMID: 23030453 Free PMC article.

9

Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.

Zhou H, Liu L, Huang J, Bernard D, Karatas H, Navarro A, Lei M, Wang S. Zhou H, et al. J Med Chem. 2013 Feb 14;56(3):1113-23. doi: 10.1021/jm3015298. Epub 2013 Jan 17. J Med Chem. 2013. PMID: 23244744

10

A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.

Aguilar A, Zhou H, Chen J, Liu L, Bai L, McEachern D, Yang CY, Meagher J, Stuckey J, Wang S. Aguilar A, et al. Among authors: zhou h. J Med Chem. 2013 Apr 11;56(7):3048-3067. doi: 10.1021/jm4001105. Epub 2013 Mar 22. J Med Chem. 2013. PMID: 23448298 Free PMC article.

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