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Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity.
Graboski AL, Simpson JB, Pellock SJ, Mehta N, Creekmore BC, Ariyarathna Y, Bhatt AP, Jariwala PB, Sekela JJ, Kowalewski ME, Barker NK, Mordant AL, Borlandelli VB, Overkleeft H, Herring LE, Jin J, I James L, Redinbo MR. Graboski AL, et al. Among authors: mehta n. RSC Chem Biol. 2024 Jul 16;5(9):853-865. doi: 10.1039/d4cb00058g. eCollection 2024 Aug 28. RSC Chem Biol. 2024. PMID: 39211470 Free PMC article.
Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception.
Pellock SJ, Creekmore BC, Walton WG, Mehta N, Biernat KA, Cesmat AP, Ariyarathna Y, Dunn ZD, Li B, Jin J, James LI, Redinbo MR. Pellock SJ, et al. Among authors: mehta n. ACS Cent Sci. 2018 Jul 25;4(7):868-879. doi: 10.1021/acscentsci.8b00239. Epub 2018 Jul 12. ACS Cent Sci. 2018. PMID: 30062115 Free PMC article.
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.
Dilworth D, Hanley RP, Ferreira de Freitas R, Allali-Hassani A, Zhou M, Mehta N, Marunde MR, Ackloo S, Carvalho Machado RA, Khalili Yazdi A, Owens DDG, Vu V, Nie DY, Alqazzaz M, Marcon E, Li F, Chau I, Bolotokova A, Qin S, Lei M, Liu Y, Szewczyk MM, Dong A, Kazemzadeh S, Abramyan T, Popova IK, Hall NW, Meiners MJ, Cheek MA, Gibson E, Kireev D, Greenblatt JF, Keogh MC, Min J, Brown PJ, Vedadi M, Arrowsmith CH, Barsyte-Lovejoy D, James LI, Schapira M. Dilworth D, et al. Among authors: mehta n. Nat Chem Biol. 2022 Jan;18(1):56-63. doi: 10.1038/s41589-021-00898-0. Epub 2021 Nov 15. Nat Chem Biol. 2022. PMID: 34782742 Free PMC article.
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.
Ferreira de Freitas R, Liu Y, Szewczyk MM, Mehta N, Li F, McLeod D, Zepeda-Velázquez C, Dilworth D, Hanley RP, Gibson E, Brown PJ, Al-Awar R, James LI, Arrowsmith CH, Barsyte-Lovejoy D, Min J, Vedadi M, Schapira M, Allali-Hassani A. Ferreira de Freitas R, et al. Among authors: mehta n. J Med Chem. 2021 Feb 11;64(3):1584-1592. doi: 10.1021/acs.jmedchem.0c01768. Epub 2021 Feb 1. J Med Chem. 2021. PMID: 33522809 Free PMC article.
Transcatheter Electrosurgical Closure of "Ventricularized" Left Atrial Appendage.
Madanat L, Jabri A, Bloomingdale R, Schott JP, Abbas AE, Renard B, Vivacqua A, Mehta N, Hanson ID. Madanat L, et al. Among authors: mehta n. JACC Cardiovasc Interv. 2024 Dec 21:S1936-8798(24)01709-6. doi: 10.1016/j.jcin.2024.11.013. Online ahead of print. JACC Cardiovasc Interv. 2024. PMID: 39846923 Free article. No abstract available.
Corrigendum: Cipaglucosidase alfa plus miglustat: linking mechanism of action to clinical outcomes in late-onset Pompe disease.
Byrne BJ, Parenti G, Schoser B, van der Ploeg AT, Do H, Fox B, Goldman M, Johnson FK, Kang J, Mehta N, Mondick J, Sheikh MO, Sitaraman Das S, Tuske S, Brudvig J, Weimer JM, Mozaffar T. Byrne BJ, et al. Among authors: mehta n. Front Neurol. 2025 Jan 3;15:1540452. doi: 10.3389/fneur.2024.1540452. eCollection 2024. Front Neurol. 2025. PMID: 39830206 Free PMC article.
2,821 results