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Page 1
Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity.
Graboski AL, Simpson JB, Pellock SJ, Mehta N, Creekmore BC, Ariyarathna Y, Bhatt AP, Jariwala PB, Sekela JJ, Kowalewski ME, Barker NK, Mordant AL, Borlandelli VB, Overkleeft H, Herring LE, Jin J, I James L, Redinbo MR. Graboski AL, et al. Among authors: kowalewski me. RSC Chem Biol. 2024 Jul 16;5(9):853-865. doi: 10.1039/d4cb00058g. eCollection 2024 Aug 28. RSC Chem Biol. 2024. PMID: 39211470 Free PMC article.
Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Simpson JB, Walker ME, Sekela JJ, Ivey SM, Jariwala PB, Storch CM, Kowalewski ME, Graboski AL, Lietzan AD, Walton WG, Davis KA, Cloer EW, Borlandelli V, Hsiao YC, Roberts LR, Perlman DH, Liang X, Overkleeft HS, Bhatt AP, Lu K, Redinbo MR. Simpson JB, et al. Among authors: kowalewski me. Cell Host Microbe. 2024 Jun 12;32(6):925-944.e10. doi: 10.1016/j.chom.2024.04.018. Epub 2024 May 15. Cell Host Microbe. 2024. PMID: 38754417 Free article.
Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development.
Carlson DL, Kowalewski M, Bodoor K, Lietzan AD, Hughes PF, Gooden D, Loiselle DR, Alcorta D, Dingman Z, Mueller EA, Irnov I, Modla S, Chaya T, Caplan J, Embers M, Miller JC, Jacobs-Wagner C, Redinbo MR, Spector N, Haystead TAJ. Carlson DL, et al. Cell Chem Biol. 2024 Mar 21;31(3):465-476.e12. doi: 10.1016/j.chembiol.2023.10.004. Epub 2023 Nov 1. Cell Chem Biol. 2024. PMID: 37918401 Free article.