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Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity.
Graboski AL, Simpson JB, Pellock SJ, Mehta N, Creekmore BC, Ariyarathna Y, Bhatt AP, Jariwala PB, Sekela JJ, Kowalewski ME, Barker NK, Mordant AL, Borlandelli VB, Overkleeft H, Herring LE, Jin J, I James L, Redinbo MR. Graboski AL, et al. Among authors: creekmore bc. RSC Chem Biol. 2024 Jul 16;5(9):853-865. doi: 10.1039/d4cb00058g. eCollection 2024 Aug 28. RSC Chem Biol. 2024. PMID: 39211470 Free PMC article.
An autosomal-dominant childhood-onset disorder associated with pathogenic variants in VCP.
Mah-Som AY, Daw J, Huynh D, Wu M, Creekmore BC, Burns W, Skinner SA, Holla ØL, Smeland MF, Planes M, Uguen K, Redon S, Bierhals T, Scholz T, Denecke J, Mensah MA, Sczakiel HL, Tichy H, Verheyen S, Blatterer J, Schreiner E, Thies J, Lam C, Spaeth CG, Pena L, Ramsey K, Narayanan V, Seaver LH, Rodriguez D, Afenjar A, Burglen L, Lee EB, Chou TF, Weihl CC, Shinawi MS. Mah-Som AY, et al. Among authors: creekmore bc. Am J Hum Genet. 2023 Nov 2;110(11):1959-1975. doi: 10.1016/j.ajhg.2023.10.007. Epub 2023 Oct 25. Am J Hum Genet. 2023. PMID: 37883978 Free PMC article.
Neurodegenerative Disease Tauopathies.
Creekmore BC, Watanabe R, Lee EB. Creekmore BC, et al. Annu Rev Pathol. 2024 Jan 24;19:345-370. doi: 10.1146/annurev-pathmechdis-051222-120750. Epub 2023 Oct 13. Annu Rev Pathol. 2024. PMID: 37832941 Free PMC article. Review.
Novel VCP activator reverses multisystem proteinopathy nuclear proteostasis defects and enhances TDP-43 aggregate clearance.
Phan JM, Creekmore BC, Nguyen AT, Bershadskaya DD, Darwich NF, Lee EB. Phan JM, et al. Among authors: creekmore bc. bioRxiv [Preprint]. 2023 Mar 15:2023.03.15.532082. doi: 10.1101/2023.03.15.532082. bioRxiv. 2023. Update in: J Clin Invest. 2024 May 23;134(14):e169039. doi: 10.1172/JCI169039 PMID: 36993559 Free PMC article. Updated. Preprint.
17 results