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Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity.
Graboski AL, Simpson JB, Pellock SJ, Mehta N, Creekmore BC, Ariyarathna Y, Bhatt AP, Jariwala PB, Sekela JJ, Kowalewski ME, Barker NK, Mordant AL, Borlandelli VB, Overkleeft H, Herring LE, Jin J, I James L, Redinbo MR. Graboski AL, et al. Among authors: borlandelli vb. RSC Chem Biol. 2024 Jul 16;5(9):853-865. doi: 10.1039/d4cb00058g. eCollection 2024 Aug 28. RSC Chem Biol. 2024. PMID: 39211470 Free PMC article.
Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate.
Simpson JB, Sekela JJ, Graboski AL, Borlandelli VB, Bivins MM, Barker NK, Sorgen AA, Mordant AL, Johnson RL, Bhatt AP, Fodor AA, Herring LE, Overkleeft H, Lee JR, Redinbo MR. Simpson JB, et al. Among authors: borlandelli vb. Gut Microbes. 2022 Jan-Dec;14(1):2107289. doi: 10.1080/19490976.2022.2107289. Gut Microbes. 2022. PMID: 35953888 Free PMC article.