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Therapeutic targeting of Syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers.
Takeda M, Theardy MS, Sorokin A, Coker O, Kanikarla P, Chen S, Yang Z, Nguyen P, Wei Y, Yao J, Wang X, Yan L, Jin Y, Cai Y, Paku M, Chen Z, Li KZ, Citron F, Tomihara H, Gao S, Deem AK, Zhao J, Wang H, Hanash S, DePinho RA, Maitra A, Draetta GF, Ying H, Kopetz S, Yao W. Takeda M, et al. Among authors: cai y. bioRxiv [Preprint]. 2024 Aug 8:2024.08.06.606865. doi: 10.1101/2024.08.06.606865. bioRxiv. 2024. PMID: 39211217 Free PMC article. Preprint.
KRAS inhibition activates an actionable CD24 'don't eat me' signal in pancreas cancer.
Wei Y, Liu M, Yen EY, Yao J, Nguyen PT, Wang X, Yang Z, Yousef A, Pan D, Jin Y, Theady MS, Park J, Cai Y, Takeda M, Vasquez M, Zhou Y, Zhao H, Viale A, Wang H, Zhao D, DePinho RA, Yao W, Ying H. Wei Y, et al. Among authors: cai y. bioRxiv [Preprint]. 2023 Sep 23:2023.09.21.558891. doi: 10.1101/2023.09.21.558891. bioRxiv. 2023. PMID: 37790498 Free PMC article. Preprint.
Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance.
Li F, Wang Y, Hwang I, Jang JY, Xu L, Deng Z, Yu EY, Cai Y, Wu C, Han Z, Huang YH, Huang X, Zhang L, Yao J, Lue NF, Lieberman PM, Ying H, Paik J, Zheng H. Li F, et al. Among authors: cai y. bioRxiv [Preprint]. 2023 Feb 11:2023.02.10.528023. doi: 10.1101/2023.02.10.528023. bioRxiv. 2023. Update in: Nat Commun. 2023 Mar 29;14(1):1756. doi: 10.1038/s41467-023-37480-2 PMID: 36798426 Free PMC article. Updated. Preprint.
Aculeapyridones A-Q, Pyranopyridone Alkaloids with Protective Effects against Acetaminophen-Induced Acute Liver Injury Discovered from a Coculture of Aspergillus aculeatinus WHUF0198 and a Penicillium sp.
Chen WC, Song X, Wu J, Zhong YT, Edjah PP, Zhang QY, Li M, Zhu KK, Tian C, Yuan RY, Wu XY, Gao P, Hong K, Zhang MK, Ping J, Cai YS. Chen WC, et al. Among authors: cai ys. J Nat Prod. 2025 Jan 28. doi: 10.1021/acs.jnatprod.4c01049. Online ahead of print. J Nat Prod. 2025. PMID: 39874532
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