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Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic risk to childhood-onset asthma.
Djeddi S, Fernandez-Salinas D, Huang GX, Aguiar VRC, Mohanty C, Kendziorski C, Gazal S, Boyce JA, Ober C, Gern JE, Barrett NA, Gutierrez-Arcelus M. Djeddi S, et al. Among authors: gutierrez arcelus m. Cell Genom. 2024 Sep 11;4(9):100636. doi: 10.1016/j.xgen.2024.100636. Epub 2024 Aug 27. Cell Genom. 2024. PMID: 39197446 Free PMC article.
Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis.
Bai Z, Bartelo N, Aslam M, Murphy EA, Hale CR, Blachere NE, Parveen S, Spolaore E, DiCarlo E, Gravallese EM, Smith MH; Accelerating Medicines Partnership RA/SLE Network; Frank MO, Jiang CS, Zhang H, Pyrgaki C, Lewis MJ, Sikandar S, Pitzalis C, Lesnak JB, Mazhar K, Price TJ, Malfait AM, Miller RE, Zhang F, Goodman S, Darnell RB, Wang F, Orange DE. Bai Z, et al. Sci Transl Med. 2024 Apr 10;16(742):eadk3506. doi: 10.1126/scitranslmed.adk3506. Epub 2024 Apr 10. Sci Transl Med. 2024. PMID: 38598614
Perspectives on ENCODE.
ENCODE Project Consortium; Snyder MP, Gingeras TR, Moore JE, Weng Z, Gerstein MB, Ren B, Hardison RC, Stamatoyannopoulos JA, Graveley BR, Feingold EA, Pazin MJ, Pagan M, Gilchrist DA, Hitz BC, Cherry JM, Bernstein BE, Mendenhall EM, Zerbino DR, Frankish A, Flicek P, Myers RM. ENCODE Project Consortium, et al. Nature. 2020 Jul;583(7818):693-698. doi: 10.1038/s41586-020-2449-8. Epub 2020 Jul 29. Nature. 2020. PMID: 32728248 Free PMC article.
Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue.
Bell RD, Brendel M, Konnaris MA, Xiang J, Otero M, Fontana MA, Bai Z; Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium; Krenitsky DM, Meednu N, Rangel-Moreno J, Scheel-Toellner D, Carr H, Nayar S, McMurray J, DiCarlo E, Anolik JH, Donlin LT, Orange DE, Kenney HM, Schwarz EM, Filer A, Ivashkiv LB, Wang F. Bell RD, et al. Nat Commun. 2024 Aug 29;15(1):7503. doi: 10.1038/s41467-024-51012-6. Nat Commun. 2024. PMID: 39209814 Free PMC article.
Type 2 inflammation drives an airway basal stem cell program through insulin receptor substrate signaling.
Wang X, Hallen NR, Lee M, Samuchiwal S, Ye Q, Buchheit KM, Maxfield AZ, Roditi RE, Bergmark RW, Bhattacharyya N, Ryan T, Gakpo D, Raychaudhuri S, Dwyer D, Laidlaw TM, Boyce JA, Gutierrez-Arcelus M, Barrett NA. Wang X, et al. J Allergy Clin Immunol. 2023 Jun;151(6):1536-1549. doi: 10.1016/j.jaci.2023.01.030. Epub 2023 Feb 17. J Allergy Clin Immunol. 2023. PMID: 36804595 Free PMC article.
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.
Kang JB, Shen AZ, Sakaue S, Luo Y, Gurajala S, Nathan A, Rumker L, Aguiar VRC, Valencia C, Lagattuta K, Zhang F, Jonsson AH, Yazar S, Alquicira-Hernandez J, Khalili H, Ananthakrishnan AN, Jagadeesh K, Dey K; Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network; Daly MJ, Xavier RJ, Donlin LT, Anolik JH, Powell JE, Rao DA, Brenner MB, Gutierrez-Arcelus M, Raychaudhuri S. Kang JB, et al. medRxiv [Preprint]. 2023 Mar 20:2023.03.14.23287257. doi: 10.1101/2023.03.14.23287257. medRxiv. 2023. Update in: Nat Genet. 2023 Dec;55(12):2255-2268. doi: 10.1038/s41588-023-01586-6 PMID: 36993194 Free PMC article. Updated. Preprint.
History of tuberculosis disease is associated with genetic regulatory variation in Peruvians.
Suliman S, Nieto-Caballero VE, Asgari S, Lopez K, Iwany SK, Luo Y, Nathan A, Fernandez-Salinas D, Chiñas M, Huang CC, Zhang Z, León SR, Calderon RI, Lecca L, Murray M, Van Rhijn I, Raychaudhuri S, Moody DB, Gutierrez-Arcelus M. Suliman S, et al. medRxiv [Preprint]. 2023 Jun 27:2023.06.20.23291558. doi: 10.1101/2023.06.20.23291558. medRxiv. 2023. Update in: PLoS Genet. 2024 Jun 13;20(6):e1011313. doi: 10.1371/journal.pgen.1011313 PMID: 37425785 Free PMC article. Updated. Preprint.
Functional genomics implicates natural killer cells in the pathogenesis of ankylosing spondylitis.
Chiñas M, Fernandez-Salinas D, Aguiar VRC, Nieto-Caballero VE, Lefton M, Nigrovic PA, Ermann J, Gutierrez-Arcelus M. Chiñas M, et al. medRxiv [Preprint]. 2024 May 9:2023.09.21.23295912. doi: 10.1101/2023.09.21.23295912. medRxiv. 2024. Update in: HGG Adv. 2025 Jan 9;6(1):100375. doi: 10.1016/j.xhgg.2024.100375 PMID: 37808698 Free PMC article. Updated. Preprint.
Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps.
Huang GX, Hallen NR, Lee M, Zheng K, Wang X, Mandanas MV, Djeddi S, Fernandez D, Hacker J, Ryan T, Bergmark RW, Bhattacharyya N, Lee S, Maxfield AZ, Roditi RE, Buchheit KM, Laidlaw TM, Gern JE, Hallstrand TS, Ray A, Wenzel SE, Boyce JA, Gutierrez-Arcelus M, Barrett NA. Huang GX, et al. bioRxiv [Preprint]. 2023 Oct 17:2023.10.13.562288. doi: 10.1101/2023.10.13.562288. bioRxiv. 2023. PMID: 37904989 Free PMC article. Preprint.
71 results