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Page 1
Antenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturation.
Carter SWD, Fee EL, Usuda H, Oguz G, Ramasamy A, Amin Z, Agnihotri B, Wei Q, Xiawen L, Takahashi T, Takahashi Y, Ikeda H, Kumagai Y, Saito Y, Saito M, Mattar C, Evans MI, Illanes SE, Jobe AH, Choolani M, Kemp MW. Carter SWD, et al. BMC Med. 2024 Aug 26;22(1):338. doi: 10.1186/s12916-024-03542-5. BMC Med. 2024. PMID: 39183288 Free PMC article.
Maternal intravenous treatment with either azithromycin or solithromycin clears Ureaplasma parvum from the amniotic fluid in an ovine model of intrauterine infection.
Miura Y, Payne MS, Keelan JA, Noe A, Carter S, Watts R, Spiller OB, Jobe AH, Kallapur SG, Saito M, Stock SJ, Newnham JP, Kemp MW. Miura Y, et al. Antimicrob Agents Chemother. 2014 Sep;58(9):5413-20. doi: 10.1128/AAC.03187-14. Epub 2014 Jun 30. Antimicrob Agents Chemother. 2014. PMID: 24982089 Free PMC article.
Successful use of an artificial placenta-based life support system to treat extremely preterm ovine fetuses compromised by intrauterine inflammation.
Usuda H, Watanabe S, Saito M, Ikeda H, Koshinami S, Sato S, Musk GC, Fee E, Carter S, Kumagai Y, Takahashi T, Takahashi Y, Kawamura S, Hanita T, Kure S, Yaegashi N, Newnham JP, Kemp MW. Usuda H, et al. Am J Obstet Gynecol. 2020 Nov;223(5):755.e1-755.e20. doi: 10.1016/j.ajog.2020.04.036. Epub 2020 May 4. Am J Obstet Gynecol. 2020. PMID: 32380175
Variability in the efficacy of a standardized antenatal steroid treatment was independent of maternal or fetal plasma drug levels: evidence from a sheep model of pregnancy.
Takahashi T, Saito M, Schmidt AF, Usuda H, Takahashi Y, Watanabe S, Hanita T, Sato S, Kumagai Y, Koshinami S, Ikeda H, Carter S, Clarke M, Fee EL, Yaegashi N, Newnham JP, Jobe AH, Kemp MW. Takahashi T, et al. Am J Obstet Gynecol. 2020 Dec;223(6):921.e1-921.e10. doi: 10.1016/j.ajog.2020.05.032. Epub 2020 May 21. Am J Obstet Gynecol. 2020. PMID: 32445634
Direct administration of the non-competitive interleukin-1 receptor antagonist rytvela transiently reduced intrauterine inflammation in an extremely preterm sheep model of chorioamnionitis.
Takahashi Y, Saito M, Usuda H, Takahashi T, Watanabe S, Hanita T, Sato S, Kumagai Y, Koshinami S, Ikeda H, Carter S, Fee EL, Furfaro L, Chemtob S, Keelan J, Olson D, Yaegashi N, Newnham JP, Jobe AH, Kemp MW. Takahashi Y, et al. PLoS One. 2021 Sep 24;16(9):e0257847. doi: 10.1371/journal.pone.0257847. eCollection 2021. PLoS One. 2021. PMID: 34559862 Free PMC article.
Betamethasone phosphate reduces the efficacy of antenatal steroid therapy and is associated with lower birthweights when administered to pregnant sheep in combination with betamethasone acetate.
Takahashi T, Fee EL, Takahashi Y, Saito M, Yaegashi N, Usuda H, Furfaro L, Carter S, Schmidt AF, Newnham JP, Jobe AH, Kemp MW. Takahashi T, et al. Am J Obstet Gynecol. 2022 Apr;226(4):564.e1-564.e14. doi: 10.1016/j.ajog.2021.10.001. Epub 2021 Oct 7. Am J Obstet Gynecol. 2022. PMID: 34626553 Free article.
Continuous but not pulsed low-dose fetal betamethasone exposures extend the durability of antenatal steroid therapy.
Takahashi T, Takahashi Y, Fee EL, Saito M, Yaegashi N, Usuda H, Bridges JP, Milad MA, Furfaro L, Carter S, Schmidt AF, Newnham JP, Jobe AH, Kemp MW. Takahashi T, et al. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 1;322(6):L784-L793. doi: 10.1152/ajplung.00018.2022. Epub 2022 Apr 5. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35380907 Free article.
One percent of the clinical dose used for antenatal steroid therapy is sufficient to induce lung maturation when administered directly to the preterm ovine fetus.
Fee EL, Takahashi T, Takahashi Y, Carter S, Furfaro L, Clarke MW, Milad MA, Usuda H, Newnham JP, Saito M, Jobe AH, Kemp MW. Fee EL, et al. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 1;322(6):L853-L865. doi: 10.1152/ajplung.00058.2022. Epub 2022 Apr 19. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35438005 Free article.
21 results