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Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension.
Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Hirenallur-Shanthappa D, Miller R, Zhang BB, Flach RJR, Kelly DP. Berger JH, et al. Among authors: hirenallur shanthappa d. Sci Rep. 2025 Jan 2;15(1):422. doi: 10.1038/s41598-024-84515-9. Sci Rep. 2025. PMID: 39747575 Free PMC article.
Metabolic Syndrome Nonalcoholic Steatohepatitis Male Mouse With Adeno-Associated Viral Renin as a Novel Model for Heart Failure With Preserved Ejection Fraction.
Shi Y, Perez-Bonilla P, Chen X, Tam K, Marshall M, Morin J, LaViolette B, Kue NR, Damilano F, Miller RA, Zhang BB, Roth Flach RJ, Hirenallur-Shanthappa D. Shi Y, et al. Among authors: hirenallur shanthappa d. J Am Heart Assoc. 2024 Dec 3;13(23):e035894. doi: 10.1161/JAHA.124.035894. Epub 2024 Nov 22. J Am Heart Assoc. 2024. PMID: 39575718 Free PMC article.
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948.
Filipski KJ, Martinez-Alsina LA, Reese MR, Evrard E, Buzon LM, Cameron KO, Zhang Y, Coffman KJ, Bradow J, Kormos BL, Liu S, Knafels JD, Sahasrabudhe PV, Chen J, Kalgutkar AS, Bessire AJ, Orozco CC, Balesano A, Cerny MA, Bollinger E, Reyes AR, Laforest B, Rosado A, Williams G, Marshall M, Tam Neale K, Chen X, Hirenallur-Shanthappa D, Stansfield JC, Groarke J, Qiu R, Karas S, Roth Flach RJ, Esler WP. Filipski KJ, et al. Among authors: hirenallur shanthappa d. J Med Chem. 2024 Nov 19. doi: 10.1021/acs.jmedchem.4c02230. Online ahead of print. J Med Chem. 2024. PMID: 39560668
Murine HSD17β13 does not control liver steatosis and modestly impacts fibrosis in a sex- and diet-specific manner.
Crane JD, Barrandon O, Faherty B, Gorgoglione M, Crowley C, Morin J, Ross TT, Shimkonis J, Li D, Hirenallur-Shanthappa D, Boucher M, Ahn Y, Clasquin MF. Crane JD, et al. Among authors: hirenallur shanthappa d. J Lipid Res. 2024 Oct;65(10):100634. doi: 10.1016/j.jlr.2024.100634. Epub 2024 Aug 24. J Lipid Res. 2024. PMID: 39182609 Free PMC article.
A modified mouse model of Friedreich's ataxia with conditional Fxn allele homozygosity delays onset of cardiomyopathy.
Perfitt TL, Huichalaf C, Gooch R, Kuperman A, Ahn Y, Chen X, Ullas S, Hirenallur-Shanthappa D, Zhan Y, Otis D, Whiteley LO, Bulawa C, Martelli A. Perfitt TL, et al. Among authors: hirenallur shanthappa d. Am J Physiol Heart Circ Physiol. 2024 Feb 1;326(2):H357-H369. doi: 10.1152/ajpheart.00496.2023. Epub 2023 Dec 1. Am J Physiol Heart Circ Physiol. 2024. PMID: 38038720
GPAT1 Deficiency in Mice Modulates NASH Progression in a Model-Dependent Manner.
Smith KR, Wang W, Miller MR, Boucher M, Reynold JE, Daurio NA, Li D, Hirenallur-Shanthappa D, Ahn Y, Beebe DA, Kelly KL, Ross TT, Bence KK, Wan M. Smith KR, et al. Among authors: hirenallur shanthappa d. Cell Mol Gastroenterol Hepatol. 2024;17(2):279-291. doi: 10.1016/j.jcmgh.2023.10.002. Epub 2023 Oct 14. Cell Mol Gastroenterol Hepatol. 2024. PMID: 37844795 Free PMC article.
Fully automated mouse echocardiography analysis using deep convolutional neural networks.
Duan C, Montgomery MK, Chen X, Ullas S, Stansfield J, McElhanon K, Hirenallur-Shanthappa D. Duan C, et al. Among authors: hirenallur shanthappa d. Am J Physiol Heart Circ Physiol. 2022 Oct 1;323(4):H628-H639. doi: 10.1152/ajpheart.00208.2022. Epub 2022 Aug 19. Am J Physiol Heart Circ Physiol. 2022. PMID: 35984765 Free article.
16 results