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Page 1
Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants.
Garnsey MR, Wang Y, Edmonds DJ, Sammons MF, Reidich B, Ahn Y, Ashkenazi Y, Carlo A, Cerny MA, Coffman KJ, Culver JA, Dechert Schmitt AM, Eng H, Fisher EL, Gutierrez JA, James L, Jordan S, Kohrt JT, Kramer M, LaChapelle EA, Lee JC, Lee J, Li D, Li Z, Liu S, Liu J, Magee TV, Miller MR, Moran M, Nason DM, Nedoma NL, O'Neil SV, Piotrowski MA, Racich J, Sommese RF, Stevens LM, Wright AS, Xiao J, Zhang L, Zhou D, Barrandon O, Clasquin MF. Garnsey MR, et al. Among authors: clasquin mf. Nat Commun. 2025 Jan 2;16(1):297. doi: 10.1038/s41467-024-54487-5. Nat Commun. 2025. PMID: 39746932 Free PMC article.
Serine catabolism generates liver NADPH and supports hepatic lipogenesis.
Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, Tesz GJ, Clasquin MF, Rabinowitz JD. Zhang Z, et al. Among authors: clasquin mf. Nat Metab. 2021 Dec;3(12):1608-1620. doi: 10.1038/s42255-021-00487-4. Epub 2021 Nov 29. Nat Metab. 2021. PMID: 34845393 Free PMC article.
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction.
Gutierrez JA, Liu W, Perez S, Xing G, Sonnenberg G, Kou K, Blatnik M, Allen R, Weng Y, Vera NB, Chidsey K, Bergman A, Somayaji V, Crowley C, Clasquin MF, Nigam A, Fulham MA, Erion DM, Ross TT, Esler WP, Magee TV, Pfefferkorn JA, Bence KK, Birnbaum MJ, Tesz GJ. Gutierrez JA, et al. Among authors: clasquin mf. Mol Metab. 2021 Jun;48:101196. doi: 10.1016/j.molmet.2021.101196. Epub 2021 Mar 3. Mol Metab. 2021. PMID: 33667726 Free PMC article. Clinical Trial.
MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.
Marjon K, Cameron MJ, Quang P, Clasquin MF, Mandley E, Kunii K, McVay M, Choe S, Kernytsky A, Gross S, Konteatis Z, Murtie J, Blake ML, Travins J, Dorsch M, Biller SA, Marks KM. Marjon K, et al. Among authors: clasquin mf. Cell Rep. 2016 Apr 19;15(3):574-587. doi: 10.1016/j.celrep.2016.03.043. Epub 2016 Apr 7. Cell Rep. 2016. PMID: 27068473 Free article.
Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer.
Patra KC, Wang Q, Bhaskar PT, Miller L, Wang Z, Wheaton W, Chandel N, Laakso M, Muller WJ, Allen EL, Jha AK, Smolen GA, Clasquin MF, Robey B, Hay N. Patra KC, et al. Among authors: clasquin mf. Cancer Cell. 2013 Aug 12;24(2):213-228. doi: 10.1016/j.ccr.2013.06.014. Epub 2013 Aug 1. Cancer Cell. 2013. PMID: 23911236 Free PMC article.
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