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Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic.
Ottensmeyer J, Esch A, Baeta H, Sieger S, Gupta Y, Rathmann MF, Jeschke A, Jacko D, Schaaf K, Schiffer T, Rahimi B, Lövenich L, Sisto A, van der Ven PFM, Fürst DO, Haas A, Bloch W, Gehlert S, Hoffmann B, Timmerman V, Huesgen PF, Höhfeld J. Ottensmeyer J, et al. Among authors: hohfeld j. Curr Biol. 2024 Sep 23;34(18):4170-4183.e9. doi: 10.1016/j.cub.2024.07.088. Epub 2024 Aug 23. Curr Biol. 2024. PMID: 39181128 Free article.
Identification of phosphatases that dephosphorylate the co-chaperone BAG3.
Kokot T, Zimmermann JP, Chand Y, Krier F, Reimann L, Scheinost L, Höfflin N, Esch A, Höhfeld J, Warscheid B, Köhn M. Kokot T, et al. Among authors: hohfeld j. Life Sci Alliance. 2024 Nov 19;8(2):e202402734. doi: 10.26508/lsa.202402734. Print 2025 Feb. Life Sci Alliance. 2024. PMID: 39562141 Free PMC article.
Maintaining proteostasis under mechanical stress.
Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B. Höhfeld J, et al. EMBO Rep. 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507. Epub 2021 Jul 26. EMBO Rep. 2021. PMID: 34309183 Free PMC article. Review.
Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy.
Kimura K, Ooms A, Graf-Riesen K, Kuppusamy M, Unger A, Schuld J, Daerr J, Lother A, Geisen C, Hein L, Takahashi S, Li G, Röll W, Bloch W, van der Ven PFM, Linke WA, Wu SM, Huesgen PF, Höhfeld J, Fürst DO, Fleischmann BK, Hesse M. Kimura K, et al. Among authors: hohfeld j. Nat Commun. 2021 Jun 11;12(1):3575. doi: 10.1038/s41467-021-23858-7. Nat Commun. 2021. PMID: 34117258 Free PMC article.
Coordinated alpha-crystallin B phosphorylation and desmin expression indicate adaptation and deadaptation to resistance exercise-induced loading in human skeletal muscle.
Jacko D, Bersiner K, Schulz O, Przyklenk A, Spahiu F, Höhfeld J, Bloch W, Gehlert S. Jacko D, et al. Among authors: hohfeld j. Am J Physiol Cell Physiol. 2020 Aug 1;319(2):C300-C312. doi: 10.1152/ajpcell.00087.2020. Epub 2020 Jun 10. Am J Physiol Cell Physiol. 2020. PMID: 32520607 Free article.
Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis.
Koehler S, Kuczkowski A, Kuehne L, Jüngst C, Hoehne M, Grahammer F, Eddy S, Kretzler M, Beck BB, Höhfeld J, Schermer B, Benzing T, Brinkkoetter PT, Rinschen MM. Koehler S, et al. Among authors: hohfeld j. J Am Soc Nephrol. 2020 Mar;31(3):544-559. doi: 10.1681/ASN.2019030312. Epub 2020 Feb 11. J Am Soc Nephrol. 2020. PMID: 32047005 Free PMC article.
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