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Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody.
Jungholm O, Trkulja C, Moche M, Srinivasa SP, Christakopoulou MN, Davidson M, Reymer A, Jardemark K, Fogaça RL, Ashok A, Jeffries G, Ampah-Korsah H, Strandback E, Andréll J, Nyman T, Nouairia G, Orwar O. Jungholm O, et al. Among authors: jardemark k. Sci Rep. 2024 Aug 23;14(1):19656. doi: 10.1038/s41598-024-70217-9. Sci Rep. 2024. PMID: 39179604 Free PMC article.
Lumateperone-mediated effects on prefrontal glutamatergic receptor-mediated neurotransmission: A dopamine D1 receptor dependent mechanism.
Titulaer J, Radhe O, Danielsson K, Dutheil S, Marcus MM, Jardemark K, Svensson TH, Snyder GL, Ericson M, Davis RE, Konradsson-Geuken Å. Titulaer J, et al. Among authors: jardemark k. Eur Neuropsychopharmacol. 2022 Sep;62:22-35. doi: 10.1016/j.euroneuro.2022.06.009. Epub 2022 Jul 22. Eur Neuropsychopharmacol. 2022. PMID: 35878581 Free article.
Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice.
Imbeault S, Gubert Olivé M, Jungholm O, Erhardt S, Wigström H, Engberg G, Jardemark K. Imbeault S, et al. Among authors: jardemark k. Int J Tryptophan Res. 2021 Aug 30;14:11786469211041368. doi: 10.1177/11786469211041368. eCollection 2021. Int J Tryptophan Res. 2021. PMID: 34483669 Free PMC article.
Rational antibody design for undruggable targets using kinetically controlled biomolecular probes.
Trkulja CL, Jungholm O, Davidson M, Jardemark K, Marcus MM, Hägglund J, Karlsson A, Karlsson R, Bruton J, Ivarsson N, Srinivasa SP, Cavallin A, Svensson P, Jeffries GDM, Christakopoulou MN, Reymer A, Ashok A, Willman G, Papadia D, Johnsson E, Orwar O. Trkulja CL, et al. Among authors: jardemark k. Sci Adv. 2021 Apr 16;7(16):eabe6397. doi: 10.1126/sciadv.abe6397. Print 2021 Apr. Sci Adv. 2021. PMID: 33863724 Free PMC article.
Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons.
Bersellini Farinotti A, Wigerblad G, Nascimento D, Bas DB, Morado Urbina C, Nandakumar KS, Sandor K, Xu B, Abdelmoaty S, Hunt MA, Ängeby Möller K, Baharpoor A, Sinclair J, Jardemark K, Lanner JT, Khmaladze I, Borm LE, Zhang L, Wermeling F, Cragg MS, Lengqvist J, Chabot-Doré AJ, Diatchenko L, Belfer I, Collin M, Kultima K, Heyman B, Jimenez-Andrade JM, Codeluppi S, Holmdahl R, Svensson CI. Bersellini Farinotti A, et al. Among authors: jardemark k. J Exp Med. 2019 Aug 5;216(8):1904-1924. doi: 10.1084/jem.20181657. Epub 2019 Jun 13. J Exp Med. 2019. PMID: 31196979 Free PMC article.
The novel antipsychotic drug brexpiprazole, alone and in combination with escitalopram, facilitates prefrontal glutamatergic transmission via a dopamine D1 receptor-dependent mechanism.
Björkholm C, Marcus MM, Konradsson-Geuken Å, Jardemark K, Svensson TH. Björkholm C, et al. Among authors: jardemark k. Eur Neuropsychopharmacol. 2017 Apr;27(4):411-417. doi: 10.1016/j.euroneuro.2017.01.014. Epub 2017 Feb 9. Eur Neuropsychopharmacol. 2017. PMID: 28190661
Alpha7 nicotinic acetylcholine receptor agonists and PAMs as adjunctive treatment in schizophrenia. An experimental study.
Marcus MM, Björkholm C, Malmerfelt A, Möller A, Påhlsson N, Konradsson-Geuken Å, Feltmann K, Jardemark K, Schilström B, Svensson TH. Marcus MM, et al. Among authors: jardemark k. Eur Neuropsychopharmacol. 2016 Sep;26(9):1401-1411. doi: 10.1016/j.euroneuro.2016.07.004. Epub 2016 Jul 26. Eur Neuropsychopharmacol. 2016. PMID: 27474687
49 results