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Page 1
Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses.
Rezaei R, Boulton S, Ahmadi M, Petryk J, Da Silva M, Kooshki Zamani N, Singaravelu R, St-Laurent G, Daniel L, Sadeghipour A, Pelin A, Poutou J, Munoz Zuniga AI, Choy C, Gilchrist VH, Khalid Z, Austin B, Onsu KA, Marius R, Ameli Z, Mohammadi F, Mancinelli V, Wang E, Nik-Akhtar A, Alwithenani A, Panahi Arasi F, Ferguson SSG, Hobman TC, Alain T, Tai LH, Ilkow CS, Diallo JS, Bell JC, Azad T. Rezaei R, et al. Among authors: alwithenani a. Nat Biomed Eng. 2024 Nov 28. doi: 10.1038/s41551-024-01259-7. Online ahead of print. Nat Biomed Eng. 2024. PMID: 39609558
Complementary dual-virus strategy drives synthetic target and cognate T-cell engager expression for endogenous-antigen agnostic immunotherapy.
Taha Z, Crupi MJF, Alluqmani N, MacKenzie D, Vallati S, Whelan JT, Fareez F, Alwithenani A, Petryk J, Chen A, Spinelli MM, Ng K, Sobh J, de Souza CT, Bharadwa PR, Lee TKH, Thomas DA, Huang BZ, Kassas O, Poutou J, Gilchrist VH, Boulton S, Thomson M, Marius R, Hooshyar M, McComb S, Arulanandam R, Ilkow CS, Bell JC, Diallo JS. Taha Z, et al. Among authors: alwithenani a. Nat Commun. 2024 Aug 23;15(1):7267. doi: 10.1038/s41467-024-51498-0. Nat Commun. 2024. PMID: 39179564 Free PMC article.
Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, sensitizes cancer cells to VSVΔ51 oncolytic virotherapy.
Wong B, Bergeron A, Maznyi G, Ng K, Jirovec A, Birdi HK, Serrano D, Spinelli M, Thomson M, Taha Z, Alwithenani A, Chen A, Lorimer I, Vanderhyden B, Arulanandam R, Diallo JS. Wong B, et al. Among authors: alwithenani a. Mol Ther. 2023 Nov 1;31(11):3176-3192. doi: 10.1016/j.ymthe.2023.09.017. Epub 2023 Sep 27. Mol Ther. 2023. PMID: 37766429 Free PMC article.
Profiling non-small cell lung cancer reveals that PD-L1 is associated with wild type EGFR and vascular invasion, and immunohistochemistry quantification of PD-L1 correlates weakly with RT-qPCR.
Alwithenani A, Bethune D, Castonguay M, Drucker A, Flowerdew G, Forsythe M, French D, Fris J, Greer W, Henteleff H, MacNeil M, Marignani P, Morzycki W, Plourde M, Snow S, Marcato P, Xu Z. Alwithenani A, et al. PLoS One. 2021 May 6;16(5):e0251080. doi: 10.1371/journal.pone.0251080. eCollection 2021. PLoS One. 2021. PMID: 33956842 Free PMC article.
Molecular profiling of non-small cell lung cancer.
Forsythe ML, Alwithenani A, Bethune D, Castonguay M, Drucker A, Flowerdew G, French D, Fris J, Greer W, Henteleff H, MacNeil M, Marignani P, Morzycki W, Plourde M, Snow S, Xu Z. Forsythe ML, et al. Among authors: alwithenani a. PLoS One. 2020 Aug 5;15(8):e0236580. doi: 10.1371/journal.pone.0236580. eCollection 2020. PLoS One. 2020. PMID: 32756609 Free PMC article.