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Shiga Toxins as Antitumor Tools.
Robert A, Wiels J. Robert A, et al. Toxins (Basel). 2021 Sep 28;13(10):690. doi: 10.3390/toxins13100690. Toxins (Basel). 2021. PMID: 34678982 Free PMC article. Review.
In vitro evaluation of NA1-115-7-loaded nanoemulsions, an MCL-1-specific inhibitor of natural origin, intended to treat B-cell lymphoproliferative disorders after oral administration.
Séguy L, Daressy F, Lahlil S, Corvaisier S, Dumontet V, Litaudon M, Apel C, Roussi F, Wiels J, Robert A, Groo AC, Malzert-Fréon A. Séguy L, et al. Among authors: robert a. Int J Pharm. 2023 Jan 5;630:122433. doi: 10.1016/j.ijpharm.2022.122433. Epub 2022 Nov 24. Int J Pharm. 2023. PMID: 36436745
NA1-115-7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal blood cells or cardiomyocytes.
Daressy F, Séguy L, Favre L, Corvaisier S, Apel C, Groo AC, Litaudon M, Dumontet V, Malzert-Fréon A, Desrat S, Roussi F, Robert A, Wiels J. Daressy F, et al. Among authors: robert a. Biomed Pharmacother. 2022 Oct;154:113546. doi: 10.1016/j.biopha.2022.113546. Epub 2022 Aug 18. Biomed Pharmacother. 2022. PMID: 35988426 Free article.
Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma.
Harrington CT, Sotillo E, Robert A, Hayer KE, Bogusz AM, Psathas J, Yu D, Taylor D, Dang CV, Klein PS, Hogarty MD, Geoerger B, El-Deiry WS, Wiels J, Thomas-Tikhonenko A. Harrington CT, et al. Among authors: robert a. Leukemia. 2019 Oct;33(10):2429-2441. doi: 10.1038/s41375-019-0454-4. Epub 2019 Mar 26. Leukemia. 2019. PMID: 30914792 Free PMC article.
1,605 results