Elgohary MK - Search Results

1

Novel anti-inflammatory agents featuring phenoxy acetic acid moiety as a pharmacophore for selective COX-2 inhibitors: Synthesis, biological evaluation, histopathological examination and molecular modeling investigation.

Elgohary MK, Abo-Ashour MF, Abd El Hadi SR, El Hassab MA, Abo-El Fetoh ME, Afify H, Abdel-Aziz HA, Abou-Seri SM. Elgohary MK, et al. Bioorg Chem. 2024 Nov;152:107727. doi: 10.1016/j.bioorg.2024.107727. Epub 2024 Aug 15. Bioorg Chem. 2024. PMID: 39167872

2

Fragment merging approach for the design of thiazole/thiazolidine clubbed pyrazoline derivatives as anti-inflammatory agents: Synthesis, biopharmacological evaluation and molecular modeling studies.

Elgohary MK, Abd El Hadi SR, Abo-Ashour MF, Abo-El Fetoh ME, Afify H, Abdel-Aziz HA, Abou-Seri SM. Elgohary MK, et al. Bioorg Chem. 2023 Oct;139:106724. doi: 10.1016/j.bioorg.2023.106724. Epub 2023 Jul 8. Bioorg Chem. 2023. PMID: 37451146

3

Design, Synthesis and Biological Assessment of N'-(2-Oxoindolin-3-ylidene)-6-methylimidazo[2,1-b]thiazole-5-carbohydrazides as Potential Anti-Proliferative Agents toward MCF-7 Breast Cancer.

Alshaye NA, Elgohary MK, Elkotamy MS, Abdel-Aziz HA. Alshaye NA, et al. Among authors: elgohary mk. Pharmaceuticals (Basel). 2024 Feb 7;17(2):216. doi: 10.3390/ph17020216. Pharmaceuticals (Basel). 2024. PMID: 38399431 Free PMC article.

4

Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny.

Alshaye NA, Elgohary MK, Elkotamy MS, Abdel-Aziz HA. Alshaye NA, et al. Among authors: elgohary mk. Molecules. 2024 Mar 15;29(6):1309. doi: 10.3390/molecules29061309. Molecules. 2024. PMID: 38542945 Free PMC article.

5

Fenamates and ibuprofen as foundational components in the synthesis of innovative, targeted COX-2 anti-inflammatory drugs, undergoing thorough biopharmacological assessments and in-silico computational studies.

Elgohary MK, Elkotamy MS, Abdelrahman Alkabbani M, Abdel-Aziz HA. Elgohary MK, et al. Bioorg Chem. 2024 Jun;147:107393. doi: 10.1016/j.bioorg.2024.107393. Epub 2024 Apr 24. Bioorg Chem. 2024. PMID: 38691908

6

Novel imidazo[2,1-b]thiazoles and imidazo[1,2-a]pyridines tethered with indolinone motif as VEGFR-2 inhibitors and apoptotic inducers: Design, synthesis and biological evaluations.

Elkotamy MS, Elgohary MK, Al-Rashood ST, Almahli H, Eldehna WM, Abdel-Aziz HA. Elkotamy MS, et al. Among authors: elgohary mk. Bioorg Chem. 2024 Oct;151:107644. doi: 10.1016/j.bioorg.2024.107644. Epub 2024 Jul 15. Bioorg Chem. 2024. PMID: 39079394

7

Development of new LSM-83177 analogues as anti-tumor agents against colorectal cancer targeting p53-MDM2 interaction.

Elgohary MK, Elkotamy MS, Al-Warhi T, Eldehna WM, Abdel-Aziz HA. Elgohary MK, et al. Bioorg Chem. 2024 Dec;153:107766. doi: 10.1016/j.bioorg.2024.107766. Epub 2024 Aug 28. Bioorg Chem. 2024. PMID: 39244969

8

Molecular docking, DFT and antiproliferative properties of 4-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine as potent anticancer agent with CDK2 and PIM1 inhibition potency.

Binjubair FA, Almansour BS, Ziedan NI, Abdel-Aziz AA, Al-Rashood ST, Elgohary MK, Elkotamy MS, Abdel-Aziz HA. Binjubair FA, et al. Among authors: elgohary mk. Drug Dev Res. 2024 Nov;85(7):e70009. doi: 10.1002/ddr.70009. Drug Dev Res. 2024. PMID: 39467111

9

Spiro-fused indoline-quinazoline hybrids as smart bombs against TNF-α-mediated inflammation.

Elkotamy MS, Elgohary MK, Alkabbani MA, Salem R, Eldehna WM, Abdel-Aziz HA. Elkotamy MS, et al. Among authors: elgohary mk. Int J Biol Macromol. 2024 Dec;283(Pt 2):137554. doi: 10.1016/j.ijbiomac.2024.137554. Epub 2024 Nov 15. Int J Biol Macromol. 2024. PMID: 39549799

10

Design, synthesis, and evaluation of novel benzofuran and pyrazole-based derivatives as dual AChE/BuChE inhibitors with antioxidant properties for Alzheimer's disease management.

Elkotamy MS, Elgohary MK, Alkabbani MA, Hefina MM, Tawfik HO, Fares M, Eldehna WM, Abdel-Aziz HA. Elkotamy MS, et al. Among authors: elgohary mk. Eur J Med Chem. 2025 Feb 5;283:117158. doi: 10.1016/j.ejmech.2024.117158. Epub 2024 Dec 10. Eur J Med Chem. 2025. PMID: 39673864

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