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A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors.
Schultheiß C, Paschold L, Mohebiany AN, Escher M, Kattimani YM, Müller M, Schmidt-Barbo P, Mensa-Vilaró A, Aróstegui JI, Boursier G, de Moreuil C, Hautala T, Willscher E, Jonas H, Chinchuluun N, Grosser B, Märkl B, Klapper W, Oommen PT, Gössling K, Hoffmann K, Tiegs G, Czernilofsky F, Dietrich S, Freeman A, Schwartz DM, Waisman A, Aksentijevich I, Binder M. Schultheiß C, et al. Among authors: tiegs g. Sci Adv. 2024 Aug 23;10(34):eadl3975. doi: 10.1126/sciadv.adl3975. Epub 2024 Aug 21. Sci Adv. 2024. PMID: 39167656 Free PMC article.
The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells.
Behler-Janbeck F, Baranowsky A, Yorgan TA, Jaeckstein MY, Worthmann A, Fuh MM, Gunasekaran K, Tiegs G, Amling M, Schinke T, Heeren J. Behler-Janbeck F, et al. Among authors: tiegs g. Front Endocrinol (Lausanne). 2024 Sep 19;15:1392418. doi: 10.3389/fendo.2024.1392418. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 39363899 Free PMC article.
Protective function of sclerosing cholangitis on IBD.
Bedke T, Stumme F, Tomczak M, Steglich B, Jia R, Bohmann S, Wittek A, Kempski J, Göke E, Böttcher M, Reher D, Franke A, Lennartz M, Clauditz T, Sauter G, Fründt T, Weidemann S, Tiegs G, Schramm C, Gagliani N, Pelczar P, Huber S. Bedke T, et al. Among authors: tiegs g. Gut. 2024 Jul 11;73(8):1292-1301. doi: 10.1136/gutjnl-2023-330856. Gut. 2024. PMID: 38839272 Free PMC article.
The ST2+ Treg/amphiregulin axis protects from immune-mediated hepatitis.
Wachtendorf S, Jonin F, Ochel A, Heinrich F, Westendorf AM, Tiegs G, Neumann K. Wachtendorf S, et al. Among authors: tiegs g. Front Immunol. 2024 Mar 20;15:1351405. doi: 10.3389/fimmu.2024.1351405. eCollection 2024. Front Immunol. 2024. PMID: 38571949 Free PMC article.
CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12.
Paust HJ, Song N, De Feo D, Asada N, Tuzlak S, Zhao Y, Riedel JH, Hellmig M, Sivayoganathan A, Peters A, Kaffke A, Borchers A, Wenzel UO, Steinmetz OM, Tiegs G, Meister E, Mack M, Kurts C, von Vietinghoff S, Lindenmeyer MT, Hoxha E, Stahl RAK, Huber TB, Bonn S, Meyer-Schwesinger C, Wiech T, Turner JE, Becher B, Krebs CF, Panzer U. Paust HJ, et al. Among authors: tiegs g. Sci Transl Med. 2023 Mar 15;15(687):eadd6137. doi: 10.1126/scitranslmed.add6137. Epub 2023 Mar 15. Sci Transl Med. 2023. PMID: 36921033
Transcriptional and Clonal Characterization of Cytotoxic T Cells in Crescentic Glomerulonephritis.
Mueller A, Zhao Y, Cicek H, Paust HJ, Sivayoganathan A, Linke A, Wegscheid C, Wiech T, Huber TB, Meyer-Schwesinger C, Bonn S, Prinz I, Panzer U, Tiegs G, Krebs CF, Neumann K. Mueller A, et al. Among authors: tiegs g. J Am Soc Nephrol. 2023 Jun 1;34(6):1003-1018. doi: 10.1681/ASN.0000000000000116. Epub 2023 Mar 13. J Am Soc Nephrol. 2023. PMID: 36913357 Free PMC article.
Glucocorticoids target the CXCL9/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury.
Riedel JH, Robben L, Paust HJ, Zhao Y, Asada N, Song N, Peters A, Kaffke A, Borchers A, Tiegs G, Seifert L, Tomas NM, Hoxha E, Wenzel UO, Huber TB, Wiech T, Turner JE, Krebs CF, Panzer U. Riedel JH, et al. Among authors: tiegs g. JCI Insight. 2023 Jan 10;8(1):e160251. doi: 10.1172/jci.insight.160251. JCI Insight. 2023. PMID: 36355429 Free PMC article.
190 results