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143 results

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Page 1
Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment.
Zhu M, Frank MW, Radka CD, Jeanfavre S, Xu J, Tse MW, Pacheco JA, Kim JS, Pierce K, Deik A, Hussain FA, Elsherbini J, Hussain S, Xulu N, Khan N, Pillay V, Mitchell CM, Dong KL, Ndung'u T, Clish CB, Rock CO, Blainey PC, Bloom SM, Kwon DS. Zhu M, et al. Among authors: pacheco ja. Cell. 2024 Sep 19;187(19):5413-5430.e29. doi: 10.1016/j.cell.2024.07.029. Epub 2024 Aug 19. Cell. 2024. PMID: 39163861 Free PMC article.
Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment.
Zhu M, Frank MW, Radka CD, Jeanfavre S, Tse MW, Pacheco JA, Pierce K, Deik A, Xu J, Hussain S, Hussain FA, Xulu N, Khan N, Pillay V, Dong KL, Ndung'u T, Clish CB, Rock CO, Blainey PC, Bloom SM, Kwon DS. Zhu M, et al. Among authors: pacheco ja. bioRxiv [Preprint]. 2023 Dec 30:2023.12.30.573720. doi: 10.1101/2023.12.30.573720. bioRxiv. 2023. Update in: Cell. 2024 Sep 19;187(19):5413-5430.e29. doi: 10.1016/j.cell.2024.07.029 PMID: 38234804 Free PMC article. Updated. Preprint.
Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria.
Li C, Stražar M, Mohamed AMT, Pacheco JA, Walker RL, Lebar T, Zhao S, Lockart J, Dame A, Thurimella K, Jeanfavre S, Brown EM, Ang QY, Berdy B, Sergio D, Invernizzi R, Tinoco A, Pishchany G, Vasan RS, Balskus E, Huttenhower C, Vlamakis H, Clish C, Shaw SY, Plichta DR, Xavier RJ. Li C, et al. Among authors: pacheco ja. Cell. 2024 Apr 11;187(8):1834-1852.e19. doi: 10.1016/j.cell.2024.03.014. Epub 2024 Apr 2. Cell. 2024. PMID: 38569543
Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy.
Fanning S, Cirka H, Thies JL, Jeong J, Niemi SM, Yoon J, Ho GPH, Pacheco JA, Dettmer U, Liu L, Clish CB, Hodgetts KJ, Hutchinson JN, Muratore CR, Caldwell GA, Caldwell KA, Selkoe D. Fanning S, et al. Among authors: pacheco ja. NPJ Parkinsons Dis. 2022 Jun 9;8(1):74. doi: 10.1038/s41531-022-00335-6. NPJ Parkinsons Dis. 2022. PMID: 35680956 Free PMC article.
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter JC, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka A. Wieder N, et al. Cell Metab. 2023 May 2;35(5):887-905.e11. doi: 10.1016/j.cmet.2023.03.018. Epub 2023 Apr 18. Cell Metab. 2023. PMID: 37075753 Free PMC article.
Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans.
Chen ZZ, Pacheco JA, Gao Y, Deng S, Peterson B, Shi X, Zheng S, Tahir UA, Katz DH, Cruz DE, Ngo D, Benson MD, Robbins JM, Guo X, Del Rocio Sevilla Gonzalez M, Manning A, Correa A, Meigs JB, Taylor KD, Rich SS, Goodarzi MO, Rotter JI, Wilson JG, Clish CB, Gerszten RE. Chen ZZ, et al. Among authors: pacheco ja. Diabetes. 2022 Nov 1;71(11):2426-2437. doi: 10.2337/db22-0033. Diabetes. 2022. PMID: 35998269 Free PMC article.
Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis.
Ardiansyah E, Pacheco JA, Nhat LTH, Dian S, Vinh DN, Hai HT, Bullock K, Alisjahbana B, Netea MG, Estiasari R, Tram TTB, Donovan J, Heemskerk D, Chau TTH, Bang ND, Ganiem AR, Ruslami R, Koeken VA, Hamers RL, Imran D, Maharani K, Kumar V, Clish CB, van Crevel R, Thwaites G, van Laarhoven A, Thuong NTT. Ardiansyah E, et al. Among authors: pacheco ja. medRxiv [Preprint]. 2023 Jan 9:2023.01.08.23284316. doi: 10.1101/2023.01.08.23284316. medRxiv. 2023. Update in: Elife. 2023 May 09;12:e85307. doi: 10.7554/eLife.85307 PMID: 36711829 Free PMC article. Updated. Preprint.
Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease.
Mehta RS, Mayers JR, Zhang Y, Bhosle A, Glasser NR, Nguyen LH, Ma W, Bae S, Branck T, Song K, Sebastian L, Pacheco JA, Seo HS, Clish C, Dhe-Paganon S, Ananthakrishnan AN, Franzosa EA, Balskus EP, Chan AT, Huttenhower C. Mehta RS, et al. Among authors: pacheco ja. Nat Med. 2023 Mar;29(3):700-709. doi: 10.1038/s41591-023-02217-7. Epub 2023 Feb 23. Nat Med. 2023. PMID: 36823301 Free PMC article.
143 results