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Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection.
Bulnes-Ramos A, Schott K, Rabinowitz J, Luchsinger C, Bertelli C, Miyagi E, Yu CH, Persaud M, Shepard C, König R, Kim B, Ivanov DN, Strebel K, Diaz-Griffero F. Bulnes-Ramos A, et al. Among authors: shepard c. mBio. 2024 Sep 11;15(9):e0195824. doi: 10.1128/mbio.01958-24. Epub 2024 Aug 20. mBio. 2024. PMID: 39162568 Free PMC article.
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
Bowen NE, Temple J, Shepard C, Oo A, Arizaga F, Kapoor-Vazirani P, Persaud M, Yu CH, Kim DH, Schinazi RF, Ivanov DN, Diaz-Griffero F, Yu DS, Xiong Y, Kim B. Bowen NE, et al. Among authors: shepard c. J Biol Chem. 2021 Oct;297(4):101170. doi: 10.1016/j.jbc.2021.101170. Epub 2021 Sep 4. J Biol Chem. 2021. PMID: 34492268 Free PMC article.
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Sommer AF, Rivière L, Qu B, Schott K, Riess M, Ni Y, Shepard C, Schnellbächer E, Finkernagel M, Himmelsbach K, Welzel K, Kettern N, Donnerhak C, Münk C, Flory E, Liese J, Kim B, Urban S, König R. Sommer AF, et al. Among authors: shepard c. Sci Rep. 2016 May 27;6:26616. doi: 10.1038/srep26616. Sci Rep. 2016. PMID: 27229711 Free PMC article.
The small-molecule 3G11 inhibits HIV-1 reverse transcription.
Opp S, Fricke T, Shepard C, Kovalskyy D, Bhattacharya A, Herkules F, Ivanov DN, Kim B, Valle-Casuso J, Diaz-Griffero F. Opp S, et al. Among authors: shepard c. Chem Biol Drug Des. 2017 Apr;89(4):608-618. doi: 10.1111/cbdd.12886. Epub 2016 Nov 15. Chem Biol Drug Des. 2017. PMID: 27748043 Free PMC article.
343 results