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Page 1
Enteroids to Study Pediatric Intestinal Drug Transport.
Streekstra EJ, Keuper-Navis M, van den Heuvel JJMW, van den Broek P, Stommel MWJ, de Boode W, Botden S, Bervoets S, O'Gorman L, Greupink R, Russel FGM, van de Steeg E, de Wildt SN. Streekstra EJ, et al. Mol Pharm. 2024 Oct 7;21(10):4983-4994. doi: 10.1021/acs.molpharmaceut.4c00339. Epub 2024 Sep 16. Mol Pharm. 2024. PMID: 39279643 Free PMC article.
Human enteroid monolayers as a potential alternative for Ussing chamber and Caco-2 monolayers to study passive permeability and drug efflux.
Streekstra EJ, Keuper-Navis M, van den Heuvel JJMW, van den Broek P, Stommel MWJ, Bervoets S, O'Gorman L, Greupink R, Russel FGM, van de Steeg E, de Wildt SN. Streekstra EJ, et al. Eur J Pharm Sci. 2024 Oct 1;201:106877. doi: 10.1016/j.ejps.2024.106877. Epub 2024 Aug 16. Eur J Pharm Sci. 2024. PMID: 39154715 Free article.
Age-Specific ADME Gene Expression in Infant Intestinal Enteroids.
Streekstra EJ, Scheer-Weijers T, Bscheider M, Fuerst-Recktenwald S, Roth A, van Ijzendoorn SCD, Botden S, de Boode W, Stommel MWJ, Greupink R, Russel FGM, van de Steeg E, de Wildt SN. Streekstra EJ, et al. Mol Pharm. 2024 Sep 2;21(9):4347-4355. doi: 10.1021/acs.molpharmaceut.4c00302. Epub 2024 Aug 9. Mol Pharm. 2024. PMID: 39120063 Free PMC article.
A proof of concept using the Ussing chamber methodology to study pediatric intestinal drug transport and age-dependent differences in absorption.
Streekstra EJ, Kiss M, van den Heuvel J, Nicolaï J, van den Broek P, Botden SMBI, Stommel MWJ, van Rijssel L, Ungell AL, van de Steeg E, Russel FGM, de Wildt SN. Streekstra EJ, et al. Clin Transl Sci. 2022 Oct;15(10):2392-2402. doi: 10.1111/cts.13368. Epub 2022 Aug 12. Clin Transl Sci. 2022. PMID: 35962572 Free PMC article.