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Vaccination of cattle with a virus vector vaccine against a major membrane protein of Mycobacterium avium subsp. paratuberculosis elicits CD8 cytotoxic T cells that kill intracellular bacteria.
Mahmoud AH, Abdellrazeq GS, Franceschi V, Schneider DA, Bannantine JP, Fry LM, Hulubei V, De Matteis G, Park KT, Minesso S, Davis WC, Donofrio G. Mahmoud AH, et al. Vet Immunol Immunopathol. 2024 Sep;275:110814. doi: 10.1016/j.vetimm.2024.110814. Epub 2024 Aug 12. Vet Immunol Immunopathol. 2024. PMID: 39142123
A peptide-based vaccine for Mycobacterium avium subspecies paratuberculosis.
Abdellrazeq GS, Elnaggar MM, Bannantine JP, Schneider DA, Souza CD, Hwang J, Mahmoud AHA, Hulubei V, Fry LM, Park KT, Davis WC. Abdellrazeq GS, et al. Vaccine. 2019 May 9;37(21):2783-2790. doi: 10.1016/j.vaccine.2019.04.040. Epub 2019 Apr 16. Vaccine. 2019. PMID: 31003915
Simultaneous cognate epitope recognition by bovine CD4 and CD8 T cells is essential for primary expansion of antigen-specific cytotoxic T-cells following ex vivo stimulation with a candidate Mycobacterium avium subsp. paratuberculosis peptide vaccine.
Abdellrazeq GS, Fry LM, Elnaggar MM, Bannantine JP, Schneider DA, Chamberlin WM, Mahmoud AHA, Park KT, Hulubei V, Davis WC. Abdellrazeq GS, et al. Vaccine. 2020 Feb 18;38(8):2016-2025. doi: 10.1016/j.vaccine.2019.12.052. Epub 2020 Jan 3. Vaccine. 2020. PMID: 31902643
Capacity to Elicit Cytotoxic CD8 T Cell Activity Against Mycobacterium avium subsp. paratuberculosis Is Retained in a Vaccine Candidate 35 kDa Peptide Modified for Expression in Mammalian Cells.
Franceschi V, Mahmoud AH, Abdellrazeq GS, Tebaldi G, Macchi F, Russo L, Fry LM, Elnaggar MM, Bannantine JP, Park KT, Hulubei V, Cavirani S, Davis WC, Donofrio G. Franceschi V, et al. Among authors: mahmoud ah. Front Immunol. 2019 Dec 11;10:2859. doi: 10.3389/fimmu.2019.02859. eCollection 2019. Front Immunol. 2019. PMID: 31921129 Free PMC article.
relA is Achilles' heel for mycobacterial pathogens as demonstrated with deletion mutants in Mycobacterium avium subsp. paratuberculosis and mycobacterium bovis bacillus Calmette-Guérin (BCG).
Abdellrazeq GS, Mahmoud AH, Park KT, Fry LM, Elnaggar MM, Schneider DA, Hulubei V, Davis WC. Abdellrazeq GS, et al. Among authors: mahmoud ah. Tuberculosis (Edinb). 2020 Jan;120:101904. doi: 10.1016/j.tube.2020.101904. Epub 2020 Jan 15. Tuberculosis (Edinb). 2020. PMID: 32090858
Advances in Understanding of the Immune Response to Mycobacterial Pathogens and Vaccines through Use of Cattle and Mycobacterium avium subsp. paratuberculosis as a Prototypic Mycobacterial Pathogen.
Davis WC, Abdellrazeq GS, Mahmoud AH, Park KT, Elnaggar MM, Donofrio G, Hulubei V, Fry LM. Davis WC, et al. Among authors: mahmoud ah. Vaccines (Basel). 2021 Sep 26;9(10):1085. doi: 10.3390/vaccines9101085. Vaccines (Basel). 2021. PMID: 34696193 Free PMC article. Review.
135 results