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Page 1
Targeted Degradation of Protein Kinase A via a Stapled Peptide PROTAC.
Whittaker MK, Bendzunas GN, Shirani M, LeClair TJ, Shebl B, Dill TC, Coffino P, Simon SM, Kennedy EJ. Whittaker MK, et al. Among authors: leclair tj. ACS Chem Biol. 2024 Sep 20;19(9):1888-1895. doi: 10.1021/acschembio.4c00237. Epub 2024 Aug 13. ACS Chem Biol. 2024. PMID: 39137166 Free PMC article.
In Silico Optimized Stapled Peptides Targeting WASF3 in Breast Cancer.
Limaye AJ, Bendzunas GN, Whittaker MK, LeClair TJ, Helton LG, Kennedy EJ. Limaye AJ, et al. Among authors: leclair tj. ACS Med Chem Lett. 2022 Mar 8;13(4):570-576. doi: 10.1021/acsmedchemlett.1c00627. eCollection 2022 Apr 14. ACS Med Chem Lett. 2022. PMID: 35450347 Free PMC article.
Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
Helton LG, Soliman A, von Zweydorf F, Kentros M, Manschwetus JT, Hall S, Gilsbach B, Ho FY, Athanasopoulos PS, Singh RK, LeClair TJ, Versées W, Raimondi F, Herberg FW, Gloeckner CJ, Rideout H, Kortholt A, Kennedy EJ. Helton LG, et al. Among authors: leclair tj. ACS Chem Biol. 2021 Nov 19;16(11):2326-2338. doi: 10.1021/acschembio.1c00487. Epub 2021 Sep 8. ACS Chem Biol. 2021. PMID: 34496561 Free article.
Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization.
Pathak P, Alexander KK, Helton LG, Kentros M, LeClair TJ, Zhang X, Ho FY, Moore TT, Hall S, Guaitoli G, Gloeckner CJ, Kortholt A, Rideout H, Kennedy EJ. Pathak P, et al. Among authors: leclair tj. ACS Chem Neurosci. 2023 Jun 7;14(11):1971-1980. doi: 10.1021/acschemneuro.3c00259. Epub 2023 May 18. ACS Chem Neurosci. 2023. PMID: 37200505 Free PMC article.