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Targeted Degradation of Protein Kinase A via a Stapled Peptide PROTAC.
Whittaker MK, Bendzunas GN, Shirani M, LeClair TJ, Shebl B, Dill TC, Coffino P, Simon SM, Kennedy EJ. Whittaker MK, et al. Among authors: kennedy ej. ACS Chem Biol. 2024 Sep 20;19(9):1888-1895. doi: 10.1021/acschembio.4c00237. Epub 2024 Aug 13. ACS Chem Biol. 2024. PMID: 39137166 Free PMC article.
Targeted disruption of PKC from AKAP signaling complexes.
Limaye AJ, Bendzunas GN, Kennedy EJ. Limaye AJ, et al. Among authors: kennedy ej. RSC Chem Biol. 2021 Jul 19;2(4):1227-1231. doi: 10.1039/d1cb00106j. eCollection 2021 Aug 5. RSC Chem Biol. 2021. PMID: 34458835 Free PMC article.
In Silico Optimized Stapled Peptides Targeting WASF3 in Breast Cancer.
Limaye AJ, Bendzunas GN, Whittaker MK, LeClair TJ, Helton LG, Kennedy EJ. Limaye AJ, et al. Among authors: kennedy ej. ACS Med Chem Lett. 2022 Mar 8;13(4):570-576. doi: 10.1021/acsmedchemlett.1c00627. eCollection 2022 Apr 14. ACS Med Chem Lett. 2022. PMID: 35450347 Free PMC article.
Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization.
Pathak P, Alexander KK, Helton LG, Kentros M, LeClair TJ, Zhang X, Ho FY, Moore TT, Hall S, Guaitoli G, Gloeckner CJ, Kortholt A, Rideout H, Kennedy EJ. Pathak P, et al. Among authors: kennedy ej. ACS Chem Neurosci. 2023 Jun 7;14(11):1971-1980. doi: 10.1021/acschemneuro.3c00259. Epub 2023 May 18. ACS Chem Neurosci. 2023. PMID: 37200505 Free PMC article.
Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
Helton LG, Soliman A, von Zweydorf F, Kentros M, Manschwetus JT, Hall S, Gilsbach B, Ho FY, Athanasopoulos PS, Singh RK, LeClair TJ, Versées W, Raimondi F, Herberg FW, Gloeckner CJ, Rideout H, Kortholt A, Kennedy EJ. Helton LG, et al. Among authors: kennedy ej. ACS Chem Biol. 2021 Nov 19;16(11):2326-2338. doi: 10.1021/acschembio.1c00487. Epub 2021 Sep 8. ACS Chem Biol. 2021. PMID: 34496561 Free article.
Targeting the WASF3 complex to suppress metastasis.
Limaye AJ, Whittaker MK, Bendzunas GN, Cowell JK, Kennedy EJ. Limaye AJ, et al. Among authors: kennedy ej. Pharmacol Res. 2022 Aug;182:106302. doi: 10.1016/j.phrs.2022.106302. Epub 2022 Jun 9. Pharmacol Res. 2022. PMID: 35691539 Review.
PKA-type I selective constrained peptide disruptors of AKAP complexes.
Wang Y, Ho TG, Franz E, Hermann JS, Smith FD, Hehnly H, Esseltine JL, Hanold LE, Murph MM, Bertinetti D, Scott JD, Herberg FW, Kennedy EJ. Wang Y, et al. Among authors: kennedy ej. ACS Chem Biol. 2015 Jun 19;10(6):1502-10. doi: 10.1021/acschembio.5b00009. Epub 2015 Mar 25. ACS Chem Biol. 2015. PMID: 25765284 Free PMC article.
77 results