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Page 1
Targeted Degradation of Protein Kinase A via a Stapled Peptide PROTAC.
Whittaker MK, Bendzunas GN, Shirani M, LeClair TJ, Shebl B, Dill TC, Coffino P, Simon SM, Kennedy EJ. Whittaker MK, et al. Among authors: coffino p. ACS Chem Biol. 2024 Sep 20;19(9):1888-1895. doi: 10.1021/acschembio.4c00237. Epub 2024 Aug 13. ACS Chem Biol. 2024. PMID: 39137166 Free PMC article.
Increased Protein Kinase A Activity Induces Fibrolamellar Hepatocellular Carcinoma Features Independent of DNAJB1.
Shirani M, Levin S, Shebl B, Requena D, Finkelstein TM, Johnson DS, Ng D, Lalazar G, Heissel S, Hojrup P, Molina H, de Jong YP, Rice CM, Singhi AD, Torbenson MS, Coffino P, Lyons B, Simon SM. Shirani M, et al. Among authors: coffino p. Cancer Res. 2024 Aug 15;84(16):2626-2644. doi: 10.1158/0008-5472.CAN-23-4110. Cancer Res. 2024. PMID: 38888469 Free PMC article.
Disruption of proteome by an oncogenic fusion kinase alters metabolism in fibrolamellar hepatocellular carcinoma.
Levin SN, Tomasini MD, Knox J, Shirani M, Shebl B, Requena D, Clark J, Heissel S, Alwaseem H, Surjan R, Lahasky R, Molina H, Torbenson MS, Lyons B, Migler RD, Coffino P, Simon SM. Levin SN, et al. Among authors: coffino p. Sci Adv. 2023 Jun 23;9(25):eadg7038. doi: 10.1126/sciadv.adg7038. Epub 2023 Jun 21. Sci Adv. 2023. PMID: 37343102 Free PMC article.
Targeting BCL-XL in fibrolamellar hepatocellular carcinoma.
Shebl B, Ng D, Lalazar G, Rosemore C, Finkelstein TM, Migler RD, Zheng G, Zhang P, Jiang CS, Qureshi A, Vaughan R, Yarchoan M, de Jong YP, Rice CM, Coffino P, Ortiz MV, Zhou D, Simon SM. Shebl B, et al. Among authors: coffino p. JCI Insight. 2022 Sep 8;7(17):e161820. doi: 10.1172/jci.insight.161820. JCI Insight. 2022. PMID: 36073545 Free PMC article.
Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening.
Lalazar G, Requena D, Ramos-Espiritu L, Ng D, Bhola PD, de Jong YP, Wang R, Narayan NJC, Shebl B, Levin S, Michailidis E, Kabbani M, Vercauteren KOA, Hurley AM, Farber BA, Hammond WJ, Saltsman JA 3rd, Weinberg EM, Glickman JF, Lyons BA, Ellison J, Schadde E, Hertl M, Leiting JL, Truty MJ, Smoot RL, Tierney F, Kato T, Wendel HG, LaQuaglia MP, Rice CM, Letai A, Coffino P, Torbenson MS, Ortiz MV, Simon SM. Lalazar G, et al. Among authors: coffino p. Cancer Discov. 2021 Oct;11(10):2544-2563. doi: 10.1158/2159-8290.CD-20-0872. Epub 2021 Jun 14. Cancer Discov. 2021. PMID: 34127480 Free PMC article.
Allosteric coupling between α-rings of the 20S proteasome.
Yu Z, Yu Y, Wang F, Myasnikov AG, Coffino P, Cheng Y. Yu Z, et al. Among authors: coffino p. Nat Commun. 2020 Sep 11;11(1):4580. doi: 10.1038/s41467-020-18415-7. Nat Commun. 2020. PMID: 32917864 Free PMC article.
Ubiquitin-independent proteasomal degradation.
Erales J, Coffino P. Erales J, et al. Among authors: coffino p. Biochim Biophys Acta. 2014 Jan;1843(1):216-21. doi: 10.1016/j.bbamcr.2013.05.008. Epub 2013 May 14. Biochim Biophys Acta. 2014. PMID: 23684952 Free PMC article. Review.
125 results