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High expression of L-GILZ transcript variant 1 (GILZ TV 1) is associated with increased 30-day sepsis mortality, and a high expression ratio possibly contraindicates hydrocortisone administration.
Rusev S, Thon P, Dyck B, Ziehe D, Rahmel T, Marko B, Palmowski L, Nowak H, Ellger B, Limper U, Schwier E, Henzler D, Ehrentraut SF, Bergmann L, Unterberg M, Adamzik M, Koos B, Rump K. Rusev S, et al. Among authors: rump k. Crit Care. 2024 Aug 12;28(1):270. doi: 10.1186/s13054-024-05056-1. Crit Care. 2024. PMID: 39135180 Free PMC article.
Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock.
Schäfer ST, Gessner S, Scherag A, Rump K, Frey UH, Siffert W, Westendorf AM, Steinmann J, Peters J, Adamzik M. Schäfer ST, et al. Among authors: rump k. PLoS One. 2014 Aug 18;9(8):e104953. doi: 10.1371/journal.pone.0104953. eCollection 2014. PLoS One. 2014. PMID: 25133403 Free PMC article.
73 results