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Page 1
AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition.
Kang H, Valerio M, Feng J, Gu L, Hoang DH, Blackmon A, Sharkas S, Pathak K, Jossart J, Li Z, Zhang H, Zhang B, Pirrotte P, Perry JJP, Hickey RJ, Malkas L, Marcucci G, Nguyen LXT. Kang H, et al. Among authors: pirrotte p. Exp Hematol Oncol. 2024 Dec 28;13(1):123. doi: 10.1186/s40164-024-00586-4. Exp Hematol Oncol. 2024. PMID: 39732733 Free PMC article.
Cardiomyocyte-derived circulating extracellular vesicles allow a non-invasive liquid biopsy of myocardium in health and disease.
Spanos M, Gokulnath P, Li G, Hutchins E, Meechoovet B, Sheng Q, Chatterjee E, Sharma R, Carnel-Amar N, Lin C, Azzam C, Ghaeli I, Amancherla KV, Victorino JF, Garcia-Mansfield K, Pfeffer R, Sahu P, Lindman BR, Elmariah S, Gamazon ER, Betti MJ, Bledsoe X, Lance ML, Absi T, Su YR, Do N, Contreras MG, Varrias D, Kladas M, Radulovic M, Tsiachris D, Spanos A, Tsioufis K, Ellinor PT, Tucker NR, Januzzi JL, Pirrotte P, Jovanovic-Talisman T, Van Keuren-Jensen K, Shah R, Das S. Spanos M, et al. Among authors: pirrotte p. medRxiv [Preprint]. 2024 Sep 22:2024.09.19.24314009. doi: 10.1101/2024.09.19.24314009. medRxiv. 2024. PMID: 39371135 Free PMC article. Preprint.
Glioblastoma vulnerability to neddylation inhibition is dependent on PTEN status, and dysregulation of the cell cycle and DNA replication.
Taylor B, Tang N, Hao Y, Lee M, Peng S, Bybee R, Hartman L, Garcia-Mansfield K, Sharma R, Pirrotte P, Ma J, Parisian AD, Furnari F, Dhruv HD, Berens ME. Taylor B, et al. Among authors: pirrotte p. Neurooncol Adv. 2024 Jun 20;6(1):vdae104. doi: 10.1093/noajnl/vdae104. eCollection 2024 Jan-Dec. Neurooncol Adv. 2024. PMID: 39119276 Free PMC article.
EGFRvIII Confers Sensitivity to Saracatinib in a STAT5-Dependent Manner in Glioblastoma.
Blomquist MR, Eghlimi R, Beniwal A, Grief D, Nascari DG, Inge L, Sereduk CP, Tuncali S, Roos A, Inforzato H, Sharma R, Pirrotte P, Mehta S, Fortin Ensign SP, Loftus JC, Tran NL. Blomquist MR, et al. Among authors: pirrotte p. Int J Mol Sci. 2024 Jun 6;25(11):6279. doi: 10.3390/ijms25116279. Int J Mol Sci. 2024. PMID: 38892466 Free PMC article.
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity.
Dong H, He X, Zhang L, Chen W, Lin YC, Liu SB, Wang H, Nguyen LXT, Li M, Zhu Y, Zhao D, Ghoda L, Serody J, Vincent B, Luznik L, Gojo I, Zeidner J, Su R, Chen J, Sharma R, Pirrotte P, Wu X, Hu W, Han W, Shen B, Kuo YH, Jin J, Salhotra A, Wang J, Marcucci G, Luo YL, Li L. Dong H, et al. Among authors: pirrotte p. Nat Cancer. 2024 Apr;5(4):601-624. doi: 10.1038/s43018-024-00736-x. Epub 2024 Feb 27. Nat Cancer. 2024. PMID: 38413714 Free PMC article.
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