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PAM-Flexible Genome Editing with an Engineered Chimeric Cas9.
Koseki S, Hong L, Yudistyra V, Stan T, Tysinger E, Silverstein R, Kramme C, Amrani N, Savic N, Pacesa M, Rodriguez T, Ponnapati M, Jacobson J, Church G, Truant R, Jinek M, Kleinstiver B, Sontheimer E, Chatterjee P. Koseki S, et al. Among authors: hong l. Res Sq [Preprint]. 2023 Mar 7:rs.3.rs-2625838. doi: 10.21203/rs.3.rs-2625838/v1. Res Sq. 2023. Update in: Nat Commun. 2023 Oct 4;14(1):6175. doi: 10.1038/s41467-023-41829-y PMID: 36945419 Free PMC article. Updated. Preprint.
PepMLM: Target Sequence-Conditioned Generation of Therapeutic Peptide Binders via Span Masked Language Modeling.
Chen T, Dumas M, Watson R, Vincoff S, Peng C, Zhao L, Hong L, Pertsemlidis S, Shaepers-Cheu M, Wang TZ, Srijay D, Monticello C, Vure P, Pulugurta R, Kholina K, Goel S, DeLisa MP, Truant R, Aguilar HC, Chatterjee P. Chen T, et al. Among authors: hong l. ArXiv [Preprint]. 2024 Aug 11:arXiv:2310.03842v3. ArXiv. 2024. PMID: 37873004 Free PMC article. Preprint.
SaLT&PepPr is an interface-predicting language model for designing peptide-guided protein degraders.
Brixi G, Ye T, Hong L, Wang T, Monticello C, Lopez-Barbosa N, Vincoff S, Yudistyra V, Zhao L, Haarer E, Chen T, Pertsemlidis S, Palepu K, Bhat S, Christopher J, Li X, Liu T, Zhang S, Petersen L, DeLisa MP, Chatterjee P. Brixi G, et al. Among authors: hong l. Commun Biol. 2023 Oct 24;6(1):1081. doi: 10.1038/s42003-023-05464-z. Commun Biol. 2023. PMID: 37875551 Free PMC article.
Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo.
Ye T, Alamgir A, Robertus CM, Colina D, Monticello C, Donahue TC, Hong L, Vincoff S, Goel S, Fekkes P, Camargo LM, Lam K, Heyes J, Putnam D, Alabi CA, Chatterjee P, DeLisa MP. Ye T, et al. Among authors: hong l. bioRxiv [Preprint]. 2024 Nov 11:2024.11.10.622803. doi: 10.1101/2024.11.10.622803. bioRxiv. 2024. PMID: 39605463 Free PMC article. Preprint.
PAM-flexible genome editing with an engineered chimeric Cas9.
Zhao L, Koseki SRT, Silverstein RA, Amrani N, Peng C, Kramme C, Savic N, Pacesa M, Rodríguez TC, Stan T, Tysinger E, Hong L, Yudistyra V, Ponnapati MR, Jacobson JM, Church GM, Jakimo N, Truant R, Jinek M, Kleinstiver BP, Sontheimer EJ, Chatterjee P. Zhao L, et al. Among authors: hong l. Nat Commun. 2023 Oct 4;14(1):6175. doi: 10.1038/s41467-023-41829-y. Nat Commun. 2023. PMID: 37794046 Free PMC article.
Correction: Increased global posterior tibial slope is significantly associated with higher ACL graft signal intensity on 2-Year postoperative MRI after primary ACL reconstruction using hamstring tendon autografts.
Zhang ZY, Hong LJ, Bai WB, Shao JY, Gao YT, Fu XY, Wang J, Wang C. Zhang ZY, et al. Among authors: hong lj. BMC Musculoskelet Disord. 2025 Jan 17;26(1):63. doi: 10.1186/s12891-025-08310-x. BMC Musculoskelet Disord. 2025. PMID: 39825301 No abstract available.
Catalytic-independent functions of the Integrator-PP2A complex (INTAC) confer sensitivity to BET inhibition.
Fan P, Shang XY, Song A, Chen S, Mao RY, Ma J, Chen J, Wang Z, Zheng H, Tao B, Hong L, Liu J, Xu W, Jiang W, Shen H, Zhang Q, Yang H, Meng XM, Lan F, Cheng J, Xu C, Zhang P, Jiang H, Chen FX. Fan P, et al. Among authors: hong l. Nat Chem Biol. 2025 Jan 14. doi: 10.1038/s41589-024-01807-x. Online ahead of print. Nat Chem Biol. 2025. PMID: 39809894
3,890 results