Crump MP - Search Results

1

An Integrated Module Performs Selective 'Online' Epoxidation in the Biosynthesis of the Antibiotic Mupirocin.

Winter AJ, de Courcy-Ireland F, Phillips AP, Barker JM, Bakar NA, Akter N, Wang L, Song Z, Crosby J, Williams C, Willis CL, Crump MP. Winter AJ, et al. Among authors: crump mp. Angew Chem Int Ed Engl. 2024 Dec 2;63(49):e202410502. doi: 10.1002/anie.202410502. Epub 2024 Oct 16. Angew Chem Int Ed Engl. 2024. PMID: 39105412

2

Conserved secondary structure in the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2) and the fatty acid synthase acyl carrier protein from Escherichia coli.

Crump MP, Crosby J, Dempsey CE, Murray M, Hopwood DA, Simpson TJ. Crump MP, et al. FEBS Lett. 1996 Aug 12;391(3):302-6. doi: 10.1016/0014-5793(96)00756-9. FEBS Lett. 1996. PMID: 8764994 Free article.

3

Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2).

Crump MP, Crosby J, Dempsey CE, Parkinson JA, Murray M, Hopwood DA, Simpson TJ. Crump MP, et al. Biochemistry. 1997 May 20;36(20):6000-8. doi: 10.1021/bi970006+. Biochemistry. 1997. PMID: 9166770

4

Acylation of Streptomyces type II polyketide synthase acyl carrier proteins.

Crosby J, Byrom KJ, Hitchman TS, Cox RJ, Crump MP, Findlow IS, Bibb MJ, Simpson TJ. Crosby J, et al. Among authors: crump mp. FEBS Lett. 1998 Aug 14;433(1-2):132-8. doi: 10.1016/s0014-5793(98)00840-0. FEBS Lett. 1998. PMID: 9738947 Free article.

5

Solution structure and dynamics of oxytetracycline polyketide synthase acyl carrier protein from Streptomyces rimosus.

Findlow SC, Winsor C, Simpson TJ, Crosby J, Crump MP. Findlow SC, et al. Among authors: crump mp. Biochemistry. 2003 Jul 22;42(28):8423-33. doi: 10.1021/bi0342259. Biochemistry. 2003. PMID: 12859187

6

The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs.

Reed MA, Schweizer M, Szafranska AE, Arthur C, Nicholson TP, Cox RJ, Crosby J, Crump MP, Simpson TJ. Reed MA, et al. Among authors: crump mp. Org Biomol Chem. 2003 Feb 7;1(3):463-71. doi: 10.1039/b208941f. Org Biomol Chem. 2003. PMID: 12926246

7

Expression, purification and preliminary X-ray diffraction analysis of a ketoreductase from a type II polyketide synthase.

Teartasin W, Limpkin C, Glod F, Spencer J, Cox RJ, Simpson TJ, Crosby J, Crump MP, Hadfield AT. Teartasin W, et al. Among authors: crump mp. Acta Crystallogr D Biol Crystallogr. 2004 Jun;60(Pt 6):1137-8. doi: 10.1107/S0907444904007905. Epub 2004 May 21. Acta Crystallogr D Biol Crystallogr. 2004. PMID: 15159580

8

The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding.

Hadfield AT, Limpkin C, Teartasin W, Simpson TJ, Crosby J, Crump MP. Hadfield AT, et al. Among authors: crump mp. Structure. 2004 Oct;12(10):1865-75. doi: 10.1016/j.str.2004.08.002. Structure. 2004. PMID: 15458634 Free article.

9

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster.

Cooper SM, Cox RJ, Crosby J, Crump MP, Hothersall J, Laosripaiboon W, Simpson TJ, Thomas CM. Cooper SM, et al. Among authors: crump mp. Chem Commun (Camb). 2005 Mar 7;(9):1179-81. doi: 10.1039/b414781b. Epub 2005 Jan 17. Chem Commun (Camb). 2005. PMID: 15726184

10

Self-malonylation is an intrinsic property of a chemically synthesized type II polyketide synthase acyl carrier protein.

Arthur CJ, Szafranska A, Evans SE, Findlow SC, Burston SG, Owen P, Clark-Lewis I, Simpson TJ, Crosby J, Crump MP. Arthur CJ, et al. Among authors: crump mp. Biochemistry. 2005 Nov 22;44(46):15414-21. doi: 10.1021/bi051499i. Biochemistry. 2005. PMID: 16285746

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