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Page 1
HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability.
Bai G, Endres T, Kühbacher U, Mengoli V, Greer BH, Peacock EM, Newton MD, Stanage T, Dello Stritto MR, Lungu R, Crossley MP, Sathirachinda A, Cortez D, Boulton SJ, Cejka P, Eichman BF, Cimprich KA. Bai G, et al. Among authors: kuhbacher u. Mol Cell. 2024 Aug 22;84(16):3044-3060.e11. doi: 10.1016/j.molcel.2024.07.018. Epub 2024 Aug 13. Mol Cell. 2024. PMID: 39142279 Free PMC article.
PARP1-dependent DNA-protein crosslink repair.
Fábián Z, Kakulidis ES, Hendriks IA, Kühbacher U, Larsen NB, Oliva-Santiago M, Wang J, Leng X, Dirac-Svejstrup AB, Svejstrup JQ, Nielsen ML, Caldecott K, Duxin JP. Fábián Z, et al. Among authors: kuhbacher u. Nat Commun. 2024 Aug 5;15(1):6641. doi: 10.1038/s41467-024-50912-x. Nat Commun. 2024. PMID: 39103378 Free PMC article.
Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway.
Liu JCY, Kühbacher U, Larsen NB, Borgermann N, Garvanska DH, Hendriks IA, Ackermann L, Haahr P, Gallina I, Guérillon C, Branigan E, Hay RT, Azuma Y, Nielsen ML, Duxin JP, Mailand N. Liu JCY, et al. Among authors: kuhbacher u. EMBO J. 2021 Sep 15;40(18):e107413. doi: 10.15252/embj.2020107413. Epub 2021 Aug 4. EMBO J. 2021. PMID: 34346517 Free PMC article.
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.
Gallina I, Hendriks IA, Hoffmann S, Larsen NB, Johansen J, Colding-Christensen CS, Schubert L, Sellés-Baiget S, Fábián Z, Kühbacher U, Gao AO, Räschle M, Rasmussen S, Nielsen ML, Mailand N, Duxin JP. Gallina I, et al. Among authors: kuhbacher u. Mol Cell. 2021 Feb 4;81(3):442-458.e9. doi: 10.1016/j.molcel.2020.11.029. Epub 2020 Dec 14. Mol Cell. 2021. PMID: 33321094 Free PMC article.
How to fix DNA-protein crosslinks.
Kühbacher U, Duxin JP. Kühbacher U, et al. DNA Repair (Amst). 2020 Oct;94:102924. doi: 10.1016/j.dnarep.2020.102924. Epub 2020 Jul 9. DNA Repair (Amst). 2020. PMID: 32683310 Free PMC article.