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A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG. Knight KM, et al. Among authors: lefevre tj. Nat Commun. 2024 Aug 5;15(1):6643. doi: 10.1038/s41467-024-50964-z. Nat Commun. 2024. PMID: 39103320 Free PMC article.
A universal allosteric mechanism for G protein activation.
Knight KM, Ghosh S, Campbell SL, Lefevre TJ, Olsen RHJ, Smrcka AV, Valentin NH, Yin G, Vaidehi N, Dohlman HG. Knight KM, et al. Among authors: lefevre tj. Mol Cell. 2021 Apr 1;81(7):1384-1396.e6. doi: 10.1016/j.molcel.2021.02.002. Epub 2021 Feb 25. Mol Cell. 2021. PMID: 33636126 Free PMC article.
Stabilization of Interdomain Interactions in G protein αi Subunits Determines Gαi Subtype Signaling Specificity.
Lefevre TJ, Wei W, Mukhaleva E, Venkata SPM, Chandan NR, Abraham S, Li Y, Dessauer CW, Vaidehi N, Smrcka AV. Lefevre TJ, et al. bioRxiv [Preprint]. 2023 Apr 6:2023.03.10.532072. doi: 10.1101/2023.03.10.532072. bioRxiv. 2023. Update in: J Biol Chem. 2024 May;300(5):107211. doi: 10.1016/j.jbc.2024.107211 PMID: 37066214 Free PMC article. Updated. Preprint.