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Peptide-scFv antigen recognition domains effectively confer CAR T cell multiantigen specificity.
Zoine JT, Immadisetty K, Ibanez-Vega J, Moore SE, Nevitt C, Thanekar U, Tian L, Karouni A, Chockley PJ, Arthur B, Sheppard H, Klco JM, Langfitt DM, Krenciute G, Gottschalk S, Babu MM, Velasquez MP. Zoine JT, et al. Among authors: chockley pj. Cell Rep Med. 2024 Feb 20;5(2):101422. doi: 10.1016/j.xcrm.2024.101422. Epub 2024 Feb 12. Cell Rep Med. 2024. PMID: 38350450 Free PMC article.
Synapse-tuned CARs enhance immune cell anti-tumor activity.
Chockley PJ, Ibanez-Vega J, Krenciute G, Talbot LJ, Gottschalk S. Chockley PJ, et al. Nat Biotechnol. 2023 Oct;41(10):1434-1445. doi: 10.1038/s41587-022-01650-2. Epub 2023 Feb 2. Nat Biotechnol. 2023. PMID: 36732477 Free PMC article.
Engineering naturally occurring CD7- T cells for the immunotherapy of hematological malignancies.
Freiwan A, Zoine JT, Crawford JC, Vaidya A, Schattgen SA, Myers JA, Patil SL, Khanlari M, Inaba H, Klco JM, Mullighan CG, Krenciute G, Chockley PJ, Naik S, Langfitt DM, Mamonkin M, Obeng EA, Thomas PG, Gottschalk S, Velasquez MP. Freiwan A, et al. Among authors: chockley pj. Blood. 2022 Dec 22;140(25):2684-2696. doi: 10.1182/blood.2021015020. Blood. 2022. PMID: 35914226 Free PMC article.