Stefan E - Search Results

1

Impact of protein and small molecule interactions on kinase conformations.

Kugler V, Schwaighofer S, Feichtner A, Enzler F, Fleischmann J, Strich S, Schwarz S, Wilson R, Tschaikner P, Troppmair J, Sexl V, Meier P, Kaserer T, Stefan E. Kugler V, et al. Among authors: stefan e. Elife. 2024 Aug 1;13:RP94755. doi: 10.7554/eLife.94755. Elife. 2024. PMID: 39088265 Free PMC article.

2

BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS.

Röck R, Mayrhofer JE, Torres-Quesada O, Enzler F, Raffeiner A, Raffeiner P, Feichtner A, Huber RG, Koide S, Taylor SS, Troppmair J, Stefan E. Röck R, et al. Among authors: stefan e. Sci Adv. 2019 Aug 14;5(8):eaav8463. doi: 10.1126/sciadv.aav8463. eCollection 2019 Aug. Sci Adv. 2019. PMID: 31453322 Free PMC article.

3

KinCon: Cell-based recording of full-length kinase conformations.

Enzler F, Tschaikner P, Schneider R, Stefan E. Enzler F, et al. Among authors: stefan e. IUBMB Life. 2020 Jun;72(6):1168-1174. doi: 10.1002/iub.2241. Epub 2020 Feb 6. IUBMB Life. 2020. PMID: 32027084 Free PMC article.

4

Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies.

Mayrhofer JE, Enzler F, Feichtner A, Röck R, Fleischmann J, Raffeiner A, Tschaikner P, Ogris E, Huber RG, Hartl M, Schneider R, Troppmair J, Torres-Quesada O, Stefan E. Mayrhofer JE, et al. Among authors: stefan e. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31105-31113. doi: 10.1073/pnas.2012150117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229534 Free PMC article.

5

Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico.

Fleischmann J, Feichtner A, DeFalco L, Kugler V, Schwaighofer S, Huber RG, Stefan E. Fleischmann J, et al. Among authors: stefan e. Biomolecules. 2021 Mar 30;11(4):518. doi: 10.3390/biom11040518. Biomolecules. 2021. PMID: 33808483 Free PMC article.

6

Targeting the Architecture of Deregulated Protein Complexes in Cancer.

Stefan E, Troppmair J, Bister K. Stefan E, et al. Adv Protein Chem Struct Biol. 2018;111:101-132. doi: 10.1016/bs.apcsb.2017.07.001. Epub 2017 Aug 18. Adv Protein Chem Struct Biol. 2018. PMID: 29459029 Review.

7

Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium.

Tschaikner P, Enzler F, Torres-Quesada O, Aanstad P, Stefan E. Tschaikner P, et al. Among authors: stefan e. Cells. 2020 Jan 3;9(1):118. doi: 10.3390/cells9010118. Cells. 2020. PMID: 31947770 Free PMC article. Review.

8

Tracking mutation and drug-driven alterations of oncokinase conformations.

Feichtner A, Kugler V, Schwaighofer S, Nuener T, Fleischmann J, Stefan E. Feichtner A, et al. Among authors: stefan e. Memo. 2022 Jun;15(2):137-142. doi: 10.1007/s12254-021-00790-6. Epub 2022 Jan 21. Memo. 2022. PMID: 35677701 Free PMC article.

9

Resistor: An algorithm for predicting resistance mutations via Pareto optimization over multistate protein design and mutational signatures.

Guerin N, Feichtner A, Stefan E, Kaserer T, Donald BR. Guerin N, et al. Among authors: stefan e. Cell Syst. 2022 Oct 19;13(10):830-843.e3. doi: 10.1016/j.cels.2022.09.003. Cell Syst. 2022. PMID: 36265469 Free PMC article.

10

Kinase perturbations redirect mitochondrial function in cancer.

Torres-Quesada O, Strich S, Stefan E. Torres-Quesada O, et al. Among authors: stefan e. Bioenerg Commun. 2022 Nov 15;2022:17. doi: 10.26124/bec:2022-0013. Bioenerg Commun. 2022. PMID: 37081928 Free PMC article.

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