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A parallel-group, multicenter randomized, double-blinded, placebo-controlled, phase 2/3, clinical trial to test the efficacy of pyridostigmine bromide at low doses to reduce mortality or invasive mechanical ventilation in adults with severe SARS-CoV-2 infection: the Pyridostigmine In Severe COvid-19 (PISCO) trial protocol.
Fragoso-Saavedra S, Iruegas-Nunez DA, Quintero-Villegas A, García-González HB, Nuñez I, Carbajal-Morelos SL, Audelo-Cruz BM, Arias-Martínez S, Caro-Vega Y, Calva JJ, Luqueño-Martínez V, González-Duarte A, Crabtree-Ramírez B, Crispín JC, Sierra-Madero J, Belaunzarán-Zamudio PF, Valdés-Ferrer SI. Fragoso-Saavedra S, et al. Among authors: nunez i. BMC Infect Dis. 2020 Oct 16;20(1):765. doi: 10.1186/s12879-020-05485-7. BMC Infect Dis. 2020. PMID: 33066761 Free PMC article.
Pyridostigmine reduces mortality of patients with severe SARS-CoV-2 infection: A phase 2/3 randomized controlled trial.
Fragoso-Saavedra S, Núñez I, Audelo-Cruz BM, Arias-Martínez S, Manzur-Sandoval D, Quintero-Villegas A, Benjamín García-González H, Carbajal-Morelos SL, PoncedeLeón-Rosales S, Gotés-Palazuelos J, Maza-Larrea JA, Rosales-de la Rosa JJ, Diaz-Rivera D, Luna-García E, Piten-Isidro E, Del Río-Estrada PM, Fragoso-Saavedra M, Caro-Vega Y, Batina I, Islas-Weinstein L, Iruegas-Nunez DA, Calva JJ, Belaunzarán-Zamudio PF, Sierra-Madero J, Crispín JC, Valdés-Ferrer SI. Fragoso-Saavedra S, et al. Among authors: nunez i. Mol Med. 2022 Nov 8;28(1):131. doi: 10.1186/s10020-022-00553-x. Mol Med. 2022. PMID: 36348276 Free PMC article. Clinical Trial.
173 results