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21 results

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Page 1
Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation.
Shah V, Giotopoulos G, Osaki H, Meyerhöfer M, Meduri E, Gallego-Crespo A, Behrendt MA, Saura-Pañella M, Tarkar A, Schubert B, Yun H, Horton SJ, Agrawal-Singh S Dr, Hähnel PS, Basheer F, Lugo D, Eleftheriadou I, Barbash O, Dhar A, Kühn M, Guezguez B, Theobald M, Kindler T, Gallipoli P, Yeh PS, Dawson MA, Prinjha RK, Huntly BJ, Sasca D. Shah V, et al. Among authors: sasca d. Blood. 2024 Dec 9:blood.2022019306. doi: 10.1182/blood.2022019306. Online ahead of print. Blood. 2024. PMID: 39651888
MoReLife - real-life data support the potential of momelotinib as a safe and effective treatment option for cytopenic myelofibrosis patients.
Jilg S, Schwaab J, Sockel K, Crodel CC, Brueckl V, Stegelmann F, Jentzsch M, Sasca D, Moyses M, Fuhrmann S, Gundel D, Caduc M, Teichmann LL, Heidel F, Al-Ali HK, Petrides PE. Jilg S, et al. Among authors: sasca d. Ann Hematol. 2024 Oct;103(10):4065-4077. doi: 10.1007/s00277-024-05908-4. Epub 2024 Jul 29. Ann Hematol. 2024. PMID: 39073589
Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma.
Briest F, Noerenberg D, Hennch C, Yoshida K, Hablesreiter R, Nimo J, Sasca D, Kirchner M, Mansouri L, Inoue Y, Wiegand L, Staiger AM, Casadei B, Korkolopoulou P, Weiner J, Lopez-Guillermo A, Warth A, Schneider T, Nagy Á, Klapper W, Hummel M, Kanellis G, Anagnostopoulos I, Mertins P, Bullinger L, Rosenquist R, Vassilakopoulos TP, Ott G, Ogawa S, Damm F. Briest F, et al. Among authors: sasca d. Leukemia. 2023 Nov;37(11):2237-2249. doi: 10.1038/s41375-023-02013-9. Epub 2023 Aug 30. Leukemia. 2023. PMID: 37648814 Free PMC article.
Menin inhibitor ziftomenib (KO-539) synergizes with drugs targeting chromatin regulation or apoptosis and sensitizes acute myeloid leukemia with MLL rearrangement or NPM1 mutation to venetoclax.
Rausch J, Dzama MM, Dolgikh N, Stiller HL, Bohl SR, Lahrmann C, Kunz K, Kessler L, Echchannaoui H, Chen CW, Kindler T, Döhner K, Burrows F, Theobald M, Sasca D, Kühn MWM. Rausch J, et al. Among authors: sasca d. Haematologica. 2023 Oct 1;108(10):2837-2843. doi: 10.3324/haematol.2022.282160. Haematologica. 2023. PMID: 37102614 Free PMC article. No abstract available.
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
Yun H, Narayan N, Vohra S, Giotopoulos G, Mupo A, Madrigal P, Sasca D, Lara-Astiaso D, Horton SJ, Agrawal-Singh S, Meduri E, Basheer F, Marando L, Gozdecka M, Dovey OM, Castillo-Venzor A, Wang X, Gallipoli P, Müller-Tidow C, Osborne CS, Vassiliou GS, Huntly BJP. Yun H, et al. Among authors: sasca d. Nat Genet. 2021 Oct;53(10):1443-1455. doi: 10.1038/s41588-021-00925-9. Epub 2021 Sep 23. Nat Genet. 2021. PMID: 34556857 Free PMC article.
Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis.
Spiecker L, Witte I, Mehlig J, Shah V, Meyerhöfer M, Haehnel PS, Petermann V, Schüler A, More P, Cabezas-Wallscheid N, Horke S, Pautz A, Daiber A, Sasca D, Kindler T, Kleinert H. Spiecker L, et al. Among authors: sasca d. Oxid Med Cell Longev. 2021 Jun 25;2021:3917028. doi: 10.1155/2021/3917028. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34257800 Free PMC article.
Treatment-Induced Aggravation of Vasculitis in Hairy-Cell Leukemia.
Rausch J, Windschmitt J, Schilling C, Butsch F, Theobald M, Sasca D, Hess G. Rausch J, et al. Among authors: sasca d. Clin Lymphoma Myeloma Leuk. 2021 May;21(5):e429-e431. doi: 10.1016/j.clml.2020.12.019. Epub 2020 Dec 23. Clin Lymphoma Myeloma Leuk. 2021. PMID: 33551343 No abstract available.
21 results