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Measuring age-dependent viscoelasticity of organelles, cells and organisms with time-shared optical tweezer microrheology.
Català-Castro F, Ortiz-Vásquez S, Martínez-Fernández C, Pezzano F, Garcia-Cabau C, Fernández-Campo M, Sanfeliu-Cerdán N, Jiménez-Delgado S, Salvatella X, Ruprecht V, Frigeri PA, Krieg M. Català-Castro F, et al. Among authors: ruprecht v. Nat Nanotechnol. 2025 Jan 2. doi: 10.1038/s41565-024-01830-y. Online ahead of print. Nat Nanotechnol. 2025. PMID: 39747604
The structure and mechanics of the cell cortex depend on the location and adhesion state.
Flormann DAD, Kainka L, Montalvo G, Anton C, Rheinlaender J, Thalla D, Vesperini D, Pohland MO, Kaub KH, Schu M, Pezzano F, Ruprecht V, Terriac E, Hawkins RJ, Lautenschläger F. Flormann DAD, et al. Among authors: ruprecht v. Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2320372121. doi: 10.1073/pnas.2320372121. Epub 2024 Jul 23. Proc Natl Acad Sci U S A. 2024. PMID: 39042691 Free article.
TANGO1 inhibitors reduce collagen secretion and limit tissue scarring.
Raote I, Rosendahl AH, Häkkinen HM, Vibe C, Küçükaylak I, Sawant M, Keufgens L, Frommelt P, Halwas K, Broadbent K, Cunquero M, Castro G, Villemeur M, Nüchel J, Bornikoel A, Dam B, Zirmire RK, Kiran R, Carolis C, Andilla J, Loza-Alvarez P, Ruprecht V, Jamora C, Campelo F, Krüger M, Hammerschmidt M, Eckes B, Neundorf I, Krieg T, Malhotra V. Raote I, et al. Among authors: ruprecht v. Nat Commun. 2024 Apr 24;15(1):3302. doi: 10.1038/s41467-024-47004-1. Nat Commun. 2024. PMID: 38658535 Free PMC article.
Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells.
Conti S, Venturini V, Cañellas-Socias A, Cortina C, Abenza JF, Stephan-Otto Attolini C, Middendorp Guerra E, Xu CK, Li JH, Rossetti L, Stassi G, Roca-Cusachs P, Diz-Muñoz A, Ruprecht V, Guck J, Batlle E, Labernadie A, Trepat X. Conti S, et al. Among authors: ruprecht v. Nat Commun. 2024 Apr 18;15(1):3363. doi: 10.1038/s41467-024-47227-2. Nat Commun. 2024. PMID: 38637494 Free PMC article.
Specialization of the photoreceptor transcriptome by Srrm3-dependent microexons is required for outer segment maintenance and vision.
Ciampi L, Mantica F, López-Blanch L, Permanyer J, Rodriguez-Marín C, Zang J, Cianferoni D, Jiménez-Delgado S, Bonnal S, Miravet-Verde S, Ruprecht V, Neuhauss SCF, Banfi S, Carrella S, Serrano L, Head SA, Irimia M. Ciampi L, et al. Among authors: ruprecht v. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2117090119. doi: 10.1073/pnas.2117090119. Epub 2022 Jul 12. Proc Natl Acad Sci U S A. 2022. PMID: 35858306 Free PMC article.
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