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Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies.
Chen S, Zhang Z, Wang Q, Yang Q, Yin L, Ning L, Chen Z, Tang J, Deng W, He P, Li H, Shi L, Deng Y, Liu Z, Bu H, Zhu Y, Liu W, Qu L, Feng L, Xiong X, Sun B, Zhong N, Li F, Li P, Chen X, Chen L. Chen S, et al. Among authors: xiong x. Signal Transduct Target Ther. 2024 Jul 22;9(1):190. doi: 10.1038/s41392-024-01906-0. Signal Transduct Target Ther. 2024. PMID: 39039046 Free PMC article.
Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients.
Yan Q, He P, Huang X, Luo K, Zhang Y, Yi H, Wang Q, Li F, Hou R, Fan X, Li P, Liu X, Liang H, Deng Y, Chen Z, Chen Y, Mo X, Feng L, Xiong X, Li S, Han J, Qu L, Niu X, Chen L. Yan Q, et al. Among authors: xiong x. Emerg Microbes Infect. 2021 Dec;10(1):1097-1111. doi: 10.1080/22221751.2021.1925594. Emerg Microbes Infect. 2021. PMID: 33944697 Free PMC article.
A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape.
Feng B, Chen Z, Sun J, Xu T, Wang Q, Yi H, Niu X, Zhu J, Fan M, Hou R, Shao Y, Huang S, Li C, Hu P, Zheng P, He P, Luo J, Yan Q, Xiong X, Liu J, Zhao J, Chen L. Feng B, et al. Among authors: xiong x. Small Methods. 2022 Jul;6(7):e2200387. doi: 10.1002/smtd.202200387. Epub 2022 May 18. Small Methods. 2022. PMID: 35583124 Free PMC article.
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope.
He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X. He P, et al. Among authors: xiong x. Nat Microbiol. 2022 Oct;7(10):1635-1649. doi: 10.1038/s41564-022-01235-4. Epub 2022 Sep 23. Nat Microbiol. 2022. PMID: 36151403 Free PMC article.
Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants.
Yu H, Liu B, Zhang Y, Gao X, Wang Q, Xiang H, Peng X, Xie C, Wang Y, Hu P, Shi J, Shi Q, Zheng P, Feng C, Tang G, Liu X, Guo L, Lin X, Li J, Liu C, Huang Y, Yang N, Chen Q, Li Z, Su M, Yan Q, Pei R, Chen X, Liu L, Hu F, Liang D, Ke B, Ke C, Li F, He J, Wang M, Chen L, Xiong X, Tang X. Yu H, et al. Among authors: xiong x. Nat Commun. 2023 Feb 24;14(1):1058. doi: 10.1038/s41467-023-36761-0. Nat Commun. 2023. PMID: 36828833 Free PMC article.
Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir.
Chen X, Huang X, Ma Q, Kuzmič P, Zhou B, Zhang S, Chen J, Xu J, Liu B, Jiang H, Zhang W, Yang C, Wu S, Huang J, Li H, Long C, Zhao X, Xu H, Sheng Y, Guo Y, Niu C, Xue L, Xu Y, Liu J, Zhang T, Spencer J, Zhu Z, Deng W, Chen X, Chen SH, Zhong N, Xiong X, Yang Z. Chen X, et al. Among authors: xiong x. Nat Microbiol. 2024 Apr;9(4):1075-1088. doi: 10.1038/s41564-024-01618-9. Epub 2024 Mar 29. Nat Microbiol. 2024. PMID: 38553607 Free PMC article.
Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variants.
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X. Yan Q, et al. Among authors: xiong x. Nat Commun. 2024 Aug 31;15(1):7585. doi: 10.1038/s41467-024-51770-3. Nat Commun. 2024. PMID: 39217172 Free PMC article.
SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses.
Carnell GW, Ciazynska KA, Wells DA, Xiong X, Aguinam ET, McLaughlin SH, Mallery D, Ebrahimi S, Ceron-Gutierrez L, Asbach B, Einhauser S, Wagner R, James LC, Doffinger R, Heeney JL, Briggs JAG. Carnell GW, et al. Among authors: xiong x. J Virol. 2021 Jul 12;95(15):e0020321. doi: 10.1128/JVI.00203-21. Epub 2021 Jul 12. J Virol. 2021. PMID: 33963055 Free PMC article.
5,782 results