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Page 1
Protective alleles and precision healthcare in crewed spaceflight.
Rutter LA, MacKay MJ, Cope H, Szewczyk NJ, Kim J, Overbey E, Tierney BT, Muratani M, Lamm B, Bezdan D, Paul AM, Schmidt MA, Church GM, Giacomello S, Mason CE. Rutter LA, et al. Among authors: mackay mj. Nat Commun. 2024 Jul 22;15(1):6158. doi: 10.1038/s41467-024-49423-6. Nat Commun. 2024. PMID: 39039045 Free PMC article. Review.
A second space age spanning omics, platforms and medicine across orbits.
Mason CE, Green J, Adamopoulos KI, Afshin EE, Baechle JJ, Basner M, Bailey SM, Bielski L, Borg J, Borg J, Broddrick JT, Burke M, Caicedo A, Castañeda V, Chatterjee S, Chin CR, Church G, Costes SV, De Vlaminck I, Desai RI, Dhir R, Diaz JE, Etlin SM, Feinstein Z, Furman D, Garcia-Medina JS, Garrett-Bakelman F, Giacomello S, Gupta A, Hassanin A, Houerbi N, Irby I, Javorsky E, Jirak P, Jones CW, Kamal KY, Kangas BD, Karouia F, Kim J, Kim JH, Kleinman AS, Lam T, Lawler JM, Lee JA, Limoli CL, Lucaci A, MacKay M, McDonald JT, Melnick AM, Meydan C, Mieczkowski J, Muratani M, Najjar D, Othman MA, Overbey EG, Paar V, Park J, Paul AM, Perdyan A, Proszynski J, Reynolds RJ, Ronca AE, Rubins K, Ryon KA, Sanders LM, Glowe PS, Shevde Y, Schmidt MA, Scott RT, Shirah B, Sienkiewicz K, Sierra MA, Siew K, Theriot CA, Tierney BT, Venkateswaran K, Hirschberg JW, Walsh SB, Walter C, Winer DA, Yu M, Zea L, Mateus J, Beheshti A. Mason CE, et al. Nature. 2024 Aug;632(8027):995-1008. doi: 10.1038/s41586-024-07586-8. Epub 2024 Jun 11. Nature. 2024. PMID: 38862027 Review.
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight.
Houerbi N, Kim J, Overbey EG, Batra R, Schweickart A, Patras L, Lucotti S, Ryon KA, Najjar D, Meydan C, Damle N, Chin C, Narayanan SA, Guarnieri JW, Widjaja G, Beheshti A, Tobias G, Vatter F, Hirschberg JW, Kleinman A, Afshin EE, MacKay M, Chen Q, Miller D, Gajadhar AS, Williamson L, Tandel P, Yang Q, Chu J, Benz R, Siddiqui A, Hornburg D, Gross S, Shirah B, Krumsiek J, Mateus J, Mao X, Matei I, Mason CE. Houerbi N, et al. Nat Commun. 2024 Jun 11;15(1):4862. doi: 10.1038/s41467-024-48841-w. Nat Commun. 2024. PMID: 38862464 Free PMC article.
Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight.
Park J, Overbey EG, Narayanan SA, Kim J, Tierney BT, Damle N, Najjar D, Ryon KA, Proszynski J, Kleinman A, Hirschberg JW, MacKay M, Afshin EE, Granstein R, Gurvitch J, Hudson BM, Rininger A, Mullane S, Church SE, Meydan C, Church G, Beheshti A, Mateus J, Mason CE. Park J, et al. Nat Commun. 2024 Jun 11;15(1):4773. doi: 10.1038/s41467-024-48625-2. Nat Commun. 2024. PMID: 38862494 Free PMC article.
Astronaut omics and the impact of space on the human body at scale.
Rutter LA, Cope H, MacKay MJ, Herranz R, Das S, Ponomarev SA, Costes SV, Paul AM, Barker R, Taylor DM, Bezdan D, Szewczyk NJ, Muratani M, Mason CE, Giacomello S. Rutter LA, et al. Among authors: mackay mj. Nat Commun. 2024 Jun 11;15(1):4952. doi: 10.1038/s41467-024-47237-0. Nat Commun. 2024. PMID: 38862505 Free PMC article. Review.
Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA).
Overbey EG, Ryon K, Kim J, Tierney BT, Klotz R, Ortiz V, Mullane S, Schmidt JC, MacKay M, Damle N, Najjar D, Matei I, Patras L, Garcia Medina JS, Kleinman AS, Wain Hirschberg J, Proszynski J, Narayanan SA, Schmidt CM, Afshin EE, Innes L, Saldarriaga MM, Schmidt MA, Granstein RD, Shirah B, Yu M, Lyden D, Mateus J, Mason CE. Overbey EG, et al. Nat Commun. 2024 Jun 11;15(1):4964. doi: 10.1038/s41467-024-48806-z. Nat Commun. 2024. PMID: 38862509 Free PMC article.
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight.
Kim J, Tierney BT, Overbey EG, Dantas E, Fuentealba M, Park J, Narayanan SA, Wu F, Najjar D, Chin CR, Meydan C, Loy C, Mathyk B, Klotz R, Ortiz V, Nguyen K, Ryon KA, Damle N, Houerbi N, Patras LI, Schanzer N, Hutchinson GA, Foox J, Bhattacharya C, Mackay M, Afshin EE, Hirschberg JW, Kleinman AS, Schmidt JC, Schmidt CM, Schmidt MA, Beheshti A, Matei I, Lyden D, Mullane S, Asadi A, Lenz JS, Mzava O, Yu M, Ganesan S, De Vlaminck I, Melnick AM, Barisic D, Winer DA, Zwart SR, Crucian BE, Smith SM, Mateus J, Furman D, Mason CE. Kim J, et al. Nat Commun. 2024 Jun 11;15(1):4954. doi: 10.1038/s41467-024-49211-2. Nat Commun. 2024. PMID: 38862516 Free PMC article.
Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight.
Tierney BT, Kim J, Overbey EG, Ryon KA, Foox J, Sierra MA, Bhattacharya C, Damle N, Najjar D, Park J, Garcia Medina JS, Houerbi N, Meydan C, Wain Hirschberg J, Qiu J, Kleinman AS, Al-Ghalith GA, MacKay M, Afshin EE, Dhir R, Borg J, Gatt C, Brereton N, Readhead BP, Beyaz S, Venkateswaran KJ, Wiseman K, Moreno J, Boddicker AM, Zhao J, Lajoie BR, Scott RT, Altomare A, Kruglyak S, Levy S, Church GM, Mason CE. Tierney BT, et al. Nat Microbiol. 2024 Jul;9(7):1661-1675. doi: 10.1038/s41564-024-01635-8. Epub 2024 Jun 11. Nat Microbiol. 2024. PMID: 38862604 Free PMC article.
Routine omics collection is a golden opportunity for European human research in space and analog environments.
Cope H, Willis CRG, MacKay MJ, Rutter LA, Toh LS, Williams PM, Herranz R, Borg J, Bezdan D, Giacomello S, Muratani M, Mason CE, Etheridge T, Szewczyk NJ. Cope H, et al. Among authors: mackay mj. Patterns (N Y). 2022 Jul 30;3(10):100550. doi: 10.1016/j.patter.2022.100550. eCollection 2022 Oct 14. Patterns (N Y). 2022. PMID: 36277820 Free PMC article. Review.
Molecular and physiological changes in the SpaceX Inspiration4 civilian crew.
Jones CW, Overbey EG, Lacombe J, Ecker AJ, Meydan C, Ryon K, Tierney B, Damle N, MacKay M, Afshin EE, Foox J, Park J, Nelson TM, Suhail Mohamad M, Byhaqui SGA, Aslam B, Tali UA, Nisa L, Menon PV, Patel CO, Khan SA, Ebert DJ, Everson A, Schubert MC, Ali NN, Sarma MS, Kim J, Houerbi N, Grigorev K, Garcia Medina JS, Summers AJ, Gu J, Altin JA, Fattahi A, Hirzallah MI, Wu JH, Stahn AC, Beheshti A, Klotz R, Ortiz V, Yu M, Patras L, Matei I, Lyden D, Melnick A, Banerjee N, Mullane S, Kleinman AS, Loesche M, Menon AS, Donoviel DB, Urquieta E, Mateus J, Sargsyan AE, Shelhamer M, Zenhausern F, Bershad EM, Basner M, Mason CE. Jones CW, et al. Nature. 2024 Aug;632(8027):1155-1164. doi: 10.1038/s41586-024-07648-x. Epub 2024 Jun 11. Nature. 2024. PMID: 38862026 Free PMC article.
66 results