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A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses.
Thimmiraju SR, Adhikari R, Redd JR, Villar MJ, Lee J, Liu Z, Chen YL, Sharma S, Kaur A, Uzcategui NL, Ronca SE, Chen WH, Kimata JT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Pollet J. Thimmiraju SR, et al. Among authors: hotez pj. NPJ Vaccines. 2024 Jul 22;9(1):132. doi: 10.1038/s41541-024-00924-x. NPJ Vaccines. 2024. PMID: 39034332 Free PMC article.
Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern.
Pollet J, Strych U, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, Thimmiraju SR, Lopez B, Gillespie PM, Ronca S, Kimata JT, Reers M, Paradkar V, Hotez P, Bottazzi ME. Pollet J, et al. bioRxiv [Preprint]. 2022 Mar 22:2021.07.06.451353. doi: 10.1101/2021.07.06.451353. bioRxiv. 2022. Update in: Vaccine. 2022 Jun 9;40(26):3655-3663. doi: 10.1016/j.vaccine.2022.05.007 PMID: 34268512 Free PMC article. Updated. Preprint.
Localized cardiac metabolic trajectories and post-infectious metabolic sequelae in experimental Chagas disease.
Liu Z, Ulrich R, Kendricks AL, Wheeler K, Leão AC, Pollet J, Bottazzi ME, Hotez P, Gusovsky F, Jones KM, McCall LI. Liu Z, et al. Res Sq [Preprint]. 2023 Jan 20:rs.3.rs-2497474. doi: 10.21203/rs.3.rs-2497474/v1. Res Sq. 2023. Update in: Nat Commun. 2023 Oct 25;14(1):6769. doi: 10.1038/s41467-023-42247-w PMID: 36711878 Free PMC article. Updated. Preprint.
The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection.
Nguyen DM, Poveda C, Pollet J, Gusovsky F, Bottazzi ME, Hotez PJ, Jones KM. Nguyen DM, et al. Among authors: hotez pj. bioRxiv [Preprint]. 2023 Jul 12:2023.07.11.548497. doi: 10.1101/2023.07.11.548497. bioRxiv. 2023. Update in: PLoS Negl Trop Dis. 2023 Nov 21;17(11):e0011519. doi: 10.1371/journal.pntd.0011519 PMID: 37503013 Free PMC article. Updated. Preprint.
Chagasin from Trypanosoma cruzi as a molecular scaffold to express epitopes of TSA-1 as soluble recombinant chimeras.
Cárdenas-Guerra RE, Montes-Flores O, Nava-Pintor EE, Reséndiz-Cardiel G, Flores-Pucheta CI, Rodríguez-Gavaldón YI, Arroyo R, Bottazzi ME, Hotez PJ, Ortega-López J. Cárdenas-Guerra RE, et al. Among authors: hotez pj. Protein Expr Purif. 2024 Jun;218:106458. doi: 10.1016/j.pep.2024.106458. Epub 2024 Feb 27. Protein Expr Purif. 2024. PMID: 38423156
Safety and immunogenicity of the co-administered Na-APR-1 and Na-GST-1 hookworm vaccines in school-aged children in Gabon: a randomised, controlled, observer-blind, phase 1, dose-escalation trial.
Zinsou JF, Diemert DJ, Dejon-Agobé JC, Adégbité BR, Honkpehedji YJ, Vodonou KG, Bikangui R, Edoa JR, Massinga Loembe M, Li G, Yazdanbakhsh M, Bottazzi ME, van Leeuwen R, Kremsner PG, Hotez PJ, Bethony JM, Grobusch MP, Adegnika AA. Zinsou JF, et al. Among authors: hotez pj. Lancet Infect Dis. 2024 Jul;24(7):760-774. doi: 10.1016/S1473-3099(24)00104-X. Epub 2024 Mar 18. Lancet Infect Dis. 2024. PMID: 38513684 Clinical Trial.
Harnessing RNA Technology to Advance Therapeutic Vaccine Antigens against Chagas Disease.
Mancino C, Pollet J, Zinger A, Jones KM, Villar MJ, Leao AC, Adhikari R, Versteeg L, Tyagi Kundu R, Strych U, Giordano F, Hotez PJ, Bottazzi ME, Taraballi F, Poveda C. Mancino C, et al. Among authors: hotez pj. ACS Appl Mater Interfaces. 2024 Apr 3;16(13):15832-15846. doi: 10.1021/acsami.3c18830. Epub 2024 Mar 22. ACS Appl Mater Interfaces. 2024. PMID: 38518375
The potential epidemiologic, clinical, and economic value of a universal coronavirus vaccine: a modelling study.
Bartsch SM, O'Shea KJ, John DC, Strych U, Bottazzi ME, Martinez MF, Ciciriello A, Chin KL, Weatherwax C, Velmurugan K, Heneghan J, Scannell SA, Hotez PJ, Lee BY. Bartsch SM, et al. Among authors: hotez pj. EClinicalMedicine. 2024 Jan 11;68:102369. doi: 10.1016/j.eclinm.2023.102369. eCollection 2024 Feb. EClinicalMedicine. 2024. PMID: 38545093 Free PMC article.
609 results