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Pancreatic CAF-derived Autotaxin (ATX) drives autocrine CTGF expression to modulate pro-tumorigenic signaling.
Volat F, Medhi R, Maggs LZ, Deken MA, Price A, Andrews L, Clark J, Taylor D, Carruthers A, Taylor-Smith E, Pacheco N, Rudge SA, Fraser A, Lopez-Clavijo AF, Sousa BC, Johnson Z, Di Conza G, van der Veen L, Shah P, Sandig H, Sharpe HJ, Farrow S. Volat F, et al. Mol Cancer Ther. 2024 Nov 21. doi: 10.1158/1535-7163.MCT-23-0522. Online ahead of print. Mol Cancer Ther. 2024. PMID: 39570650
Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen.
Robertson AL, Ogryzko NV, Henry KM, Loynes CA, Foulkes MJ, Meloni MM, Wang X, Ford C, Jackson M, Ingham PW, Wilson HL, Farrow SN, Solari R, Flower RJ, Jones S, Whyte MK, Renshaw SA. Robertson AL, et al. Among authors: farrow sn. Dis Model Mech. 2016 Jun 1;9(6):621-32. doi: 10.1242/dmm.024935. Epub 2016 Apr 14. Dis Model Mech. 2016. PMID: 27079522 Free PMC article.
Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.
Matthews LC, Berry AA, Morgan DJ, Poolman TM, Bauer K, Kramer F, Spiller DG, Richardson RV, Chapman KE, Farrow SN, Norman MR, Williamson AJ, Whetton AD, Taylor SS, Tuckermann JP, White MR, Ray DW. Matthews LC, et al. Among authors: farrow sn. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5479-84. doi: 10.1073/pnas.1411356112. Epub 2015 Apr 6. Proc Natl Acad Sci U S A. 2015. PMID: 25847991 Free PMC article.
A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.
Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza B, Willson J, Walmsley SR, Anderson SR, Coles MC, Farrow SN, Solari R, Jones S, Prince LR, Irimia D, Rainger GE, Kadirkamanathan V, Whyte MK, Renshaw SA. Robertson AL, et al. Among authors: farrow sn. Sci Transl Med. 2014 Feb 26;6(225):225ra29. doi: 10.1126/scitranslmed.3007672. Sci Transl Med. 2014. PMID: 24574340 Free PMC article.
52 results