Zhang Y - Search Results

1

Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2.

Zheng M, Feng B, Zhang Y, Liu X, Zhao N, Liu H, Xu Z, He X, Qu Z, Chen S, Jiang Z, Cheng X, Liu H, Zang Y, Zhao L, Zheng J, Zhang L, Li J, Zhou Y. Zheng M, et al. Among authors: zhang l, zhang y. Acta Pharm Sin B. 2024 Jul;14(7):3286-3290. doi: 10.1016/j.apsb.2024.04.011. Epub 2024 Apr 15. Acta Pharm Sin B. 2024. PMID: 39027261 Free PMC article. No abstract available.

2

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease.

Su H, Yao S, Zhao W, Zhang Y, Liu J, Shao Q, Wang Q, Li M, Xie H, Shang W, Ke C, Feng L, Jiang X, Shen J, Xiao G, Jiang H, Zhang L, Ye Y, Xu Y. Su H, et al. Among authors: zhang l, zhang y. Nat Commun. 2021 Jun 15;12(1):3623. doi: 10.1038/s41467-021-23751-3. Nat Commun. 2021. PMID: 34131140 Free PMC article.

3

Probing the Allosteric Inhibition Mechanism of a Spike Protein Using Molecular Dynamics Simulations and Active Compound Identifications.

Wang Q, Wang L, Zhang Y, Zhang X, Zhang L, Shang W, Bai F. Wang Q, et al. Among authors: zhang l, zhang x, zhang y. J Med Chem. 2022 Feb 24;65(4):2827-2835. doi: 10.1021/acs.jmedchem.1c00320. Epub 2021 Aug 20. J Med Chem. 2022. PMID: 34415156

4

Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2.

Xie Y, Yin W, Zhang Y, Shang W, Wang Z, Luan X, Tian G, Aisa HA, Xu Y, Xiao G, Li J, Jiang H, Zhang S, Zhang L, Xu HE, Shen J. Xie Y, et al. Among authors: zhang l, zhang s, zhang y. Cell Res. 2021 Nov;31(11):1212-1214. doi: 10.1038/s41422-021-00570-1. Epub 2021 Sep 28. Cell Res. 2021. PMID: 34584244 Free PMC article. No abstract available.

5

Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model.

Zhang R, Zhang Y, Zheng W, Shang W, Wu Y, Li N, Xiong J, Jiang H, Shen J, Xiao G, Xie Y, Zhang L. Zhang R, et al. Among authors: zhang l, zhang y. Signal Transduct Target Ther. 2022 Apr 16;7(1):123. doi: 10.1038/s41392-022-00963-7. Signal Transduct Target Ther. 2022. PMID: 35429988 Free PMC article. No abstract available.

6

Discovery of novel non-peptidic and non-covalent small-molecule 3CL^pro inhibitors as potential candidate for COVID-19 treatment.

Jiang Z, Feng B, Zhang Y, Nie T, Liu H, Li J, Su H, Zhang L, Zang Y, Zhou Y. Jiang Z, et al. Among authors: zhang l, zhang y. Signal Transduct Target Ther. 2023 May 22;8(1):209. doi: 10.1038/s41392-023-01482-9. Signal Transduct Target Ther. 2023. PMID: 37217487 Free PMC article. No abstract available.

7

Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CL^pro inhibitors against SARS-CoV-2.

Yang H, You M, Shu X, Zhen J, Zhu M, Fu T, Zhang Y, Jiang X, Zhang L, Xu Y, Zhang Y, Su H, Zhang Q, Shen J. Yang H, et al. Among authors: zhang l, zhang q, zhang y. Eur J Med Chem. 2023 Sep 5;257:115512. doi: 10.1016/j.ejmech.2023.115512. Epub 2023 May 23. Eur J Med Chem. 2023. PMID: 37253309 Free PMC article.

8

A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir.

Zhang Y, Sun Y, Xie Y, Shang W, Wang Z, Jiang H, Shen J, Xiao G, Zhang L. Zhang Y, et al. Among authors: zhang l. Signal Transduct Target Ther. 2023 Sep 22;8(1):360. doi: 10.1038/s41392-023-01587-1. Signal Transduct Target Ther. 2023. PMID: 37735468 Free PMC article.

9

Correction: Discovery of novel non-peptidic and non-covalent small-molecule 3CL^pro inhibitors as potential candidate for COVID-19 treatment.

Jiang Z, Feng B, Zhang Y, Nie T, Liu H, Li J, Su H, Zhang L, Zang Y, Zhou Y. Jiang Z, et al. Among authors: zhang l, zhang y. Signal Transduct Target Ther. 2023 Oct 13;8(1):407. doi: 10.1038/s41392-023-01665-4. Signal Transduct Target Ther. 2023. PMID: 37833245 Free PMC article. No abstract available.

10

Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry.

Wang H, Yang Q, Liu X, Xu Z, Shao M, Li D, Duan Y, Tang J, Yu X, Zhang Y, Hao A, Wang Y, Chen J, Zhu C, Guddat L, Chen H, Zhang L, Chen X, Jiang B, Sun L, Rao Z, Yang H. Wang H, et al. Among authors: zhang l, zhang y. Nat Commun. 2023 Nov 21;14(1):7574. doi: 10.1038/s41467-023-42527-5. Nat Commun. 2023. PMID: 37990007 Free PMC article.

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