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Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice.
Li D, Wei R, Zhang X, Gong S, Wan M, Wang F, Li J, Chen M, Liu R, Wan Y, Hong Y, Zeng Z, Gu P, Wang Z, Selva Nandakumar K, Jiang Y, Zhou H, Chen P. Li D, et al. Among authors: liu r. Acta Pharm Sin B. 2024 Jul;14(7):3068-3085. doi: 10.1016/j.apsb.2024.03.025. Epub 2024 Mar 22. Acta Pharm Sin B. 2024. PMID: 39027244 Free PMC article.
Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis.
Li J, Chen Y, Li R, Zhang X, Chen T, Mei F, Liu R, Chen M, Ge Y, Hu H, Wei R, Chen Z, Fan H, Zeng Z, Deng Y, Luo H, Hu S, Cai S, Wu F, Shi N, Wang Z, Zeng Y, Xie M, Jiang Y, Chen Z, Jia W, Chen P. Li J, et al. Among authors: liu r. Mol Ther. 2023 Apr 5;31(4):1017-1032. doi: 10.1016/j.ymthe.2023.01.018. Epub 2023 Jan 24. Mol Ther. 2023. PMID: 36698311 Free PMC article.
A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis.
Gu P, Liu R, Yang Q, Xie L, Wei R, Li J, Mei F, Chen T, Zeng Z, He Y, Zhou H, Peng H, Nandakumar KS, Chu H, Jiang Y, Gong W, Chen Y, Schnabl B, Chen P. Gu P, et al. Among authors: liu r. Cell Mol Immunol. 2023 Oct;20(10):1156-1170. doi: 10.1038/s41423-023-01070-5. Epub 2023 Aug 9. Cell Mol Immunol. 2023. PMID: 37553429 Free PMC article.
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