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The fate of secretory cells during intestinal homeostasis, regeneration, and tumor formation is regulated by Tcf4.
Janeckova L, Stastna M, Hrckulak D, Berkova L, Kubovciak J, Onhajzer J, Kriz V, Dostalikova S, Mullerova T, Vecerkova K, Tenglerova M, Coufal S, Kostovcikova K, Blumberg RS, Filipp D, Basler K, Valenta T, Kolar M, Korinek V. Janeckova L, et al. Among authors: blumberg rs. bioRxiv [Preprint]. 2024 Jul 11:2024.07.11.603019. doi: 10.1101/2024.07.11.603019. bioRxiv. 2024. PMID: 39026783 Free PMC article. Preprint.
IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
Lin X, Gaudino SJ, Jang KK, Bahadur T, Singh A, Banerjee A, Beaupre M, Chu T, Wong HT, Kim CK, Kempen C, Axelrad J, Huang H, Khalid S, Shah V, Eskiocak O, Parks OB, Berisha A, McAleer JP, Good M, Hoshino M, Blumberg R, Bialkowska AB, Gaffen SL, Kolls JK, Yang VW, Beyaz S, Cadwell K, Kumar P. Lin X, et al. Immunity. 2022 Feb 8;55(2):237-253.e8. doi: 10.1016/j.immuni.2021.12.016. Epub 2022 Jan 25. Immunity. 2022. PMID: 35081371 Free PMC article.
Epithelial calcineurin controls microbiota-dependent intestinal tumor development.
Peuker K, Muff S, Wang J, Künzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink GR, Schafmayer C, Egberts JH, Becker T, Bianchi ME, Bleich A, Röcken C, Hampe J, Schreiber S, Baines JF, Blumberg RS, Zeissig S. Peuker K, et al. Among authors: blumberg rs. Nat Med. 2016 May;22(5):506-15. doi: 10.1038/nm.4072. Epub 2016 Apr 4. Nat Med. 2016. PMID: 27043494 Free PMC article.
Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis.
Welz L, Kakavand N, Hang X, Laue G, Ito G, Silva MG, Plattner C, Mishra N, Tengen F, Ogris C, Jesinghaus M, Wottawa F, Arnold P, Kaikkonen L, Stengel S, Tran F, Das S, Kaser A, Trajanoski Z, Blumberg R, Roecken C, Saur D, Tschurtschenthaler M, Schreiber S, Rosenstiel P, Aden K. Welz L, et al. Gastroenterology. 2022 Jan;162(1):223-237.e11. doi: 10.1053/j.gastro.2021.09.057. Epub 2021 Sep 30. Gastroenterology. 2022. PMID: 34599932 Free PMC article.
Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι.
Nakanishi Y, Reina-Campos M, Nakanishi N, Llado V, Elmen L, Peterson S, Campos A, De SK, Leitges M, Ikeuchi H, Pellecchia M, Blumberg RS, Diaz-Meco MT, Moscat J. Nakanishi Y, et al. Among authors: blumberg rs. Cell Rep. 2016 Sep 20;16(12):3297-3310. doi: 10.1016/j.celrep.2016.08.054. Cell Rep. 2016. PMID: 27653691 Free PMC article.
Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation.
Tamura T, Cheng C, Villaseñor-Altamirano AB, Yamada K, Ikeda K, Hayashida K, Menon JA, Chen XD, Chung H, Varon J, Chen J, Choi J, Cullen AM, Guo J, Lin X, Olenchock BA, Pinilla-Vera MA, Manandhar R, Sheikh MDA, Hou PC, Lawler PR, Oldham WM, Seethala RR; Immunology of Cardiac Arrest Network (I-CAN); Baron RM, Bohula EA, Morrow DA, Blumberg RS, Chen F, Merriam LT, Weissman AJ, Brenner MB, Chen X, Ichinose F, Kim EY. Tamura T, et al. Among authors: blumberg rs. Sci Transl Med. 2024 Dec 4;16(776):eadq5796. doi: 10.1126/scitranslmed.adq5796. Epub 2024 Dec 4. Sci Transl Med. 2024. PMID: 39630883
Structural aspects of CEACAM1 interactions.
Gandhi AK, Huang YH, Sun ZJ, Kim WM, Kondo Y, Hanley T, Beauchemin N, Blumberg RS. Gandhi AK, et al. Among authors: blumberg rs. Eur J Clin Invest. 2024 Dec;54 Suppl 2:e14357. doi: 10.1111/eci.14357. Epub 2024 Nov 18. Eur J Clin Invest. 2024. PMID: 39555955 Review.
353 results